The phenomenon of anhydrobiosis-structural and functional changes in yeast cells.

IF 3.9 3区 生物学 Q2 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Marek Kieliszek
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Abstract

Anhydrobiosis is a phenomenon that involves the ability of microorganisms to survive in an environment of virtually complete dehydration. Yeast cells in anhydrobiosis exhibit several structural and functional changes. Survival of such extreme environmental conditions while maintaining the viability of eukaryotic cells after rehydration is a subject of constant interest in the scientific community worldwide. This review article presents the most essential information discussing the effect of dehydration on several structural and functional changes occurring in yeast cell organelles. It is worth emphasizing that at the cellular level, in dehydration conditions, it is possible to observe the occurrence of processes responsible for cytoplasm condensation, cytoskeleton reorganization or changes in the structure of the cell membrane and individual organelles. In addition, protein aggregation and a reduction in metabolic activity also occur. The consequence of such processes is the inhibition of the cell cycle and a decrease in the activity of individual enzymes. One of the key mechanisms responsible for yeast defense against this phenomenon is the accumulation of protective substances. Understanding the functioning of complex adaptive mechanisms of yeast cells occurring in the state of anhydrobiosis will constitute an extension of the current knowledge in this scientific field. It is worth emphasizing that conducting future research on explaining the complex relationships that occur at the molecular level in the cytosol of yeast cells between individual organelles will provide new molecular clues covering the functioning of particular signaling pathways. At the same time, using knowledge from this technological sector will be an opportunity to develop innovative technologies in the field of designing yeast-derived products. KEY POINTS: • Yeast cells exhibit significant structural and functional changes in the anhydrobiosis state. • Dehydration leads to cytoskeleton reorganization, membrane changes, and cytoplasmic condensation. • Anhydrobiosis leads to protein aggregation and reduced translation at the ribosome level in yeast.

无水现象——酵母细胞的结构和功能变化。
无水是一种现象,涉及微生物在几乎完全脱水的环境中生存的能力。酵母细胞在无水状态下表现出一些结构和功能上的变化。在这种极端的环境条件下生存,同时保持真核细胞在补液后的活力,是全世界科学界一直感兴趣的课题。本文综述了脱水对酵母细胞器发生的几种结构和功能变化的影响。值得强调的是,在细胞水平上,在脱水条件下,可以观察到细胞质凝聚、细胞骨架重组或细胞膜和单个细胞器结构变化过程的发生。此外,蛋白质聚集和代谢活性降低也会发生。这些过程的结果是抑制细胞周期和降低单个酶的活性。酵母防御这种现象的关键机制之一是保护性物质的积累。了解酵母细胞在无水状态下的复杂适应机制的功能将构成这一科学领域现有知识的延伸。值得强调的是,对酵母细胞质中单个细胞器之间在分子水平上发生的复杂关系进行解释的未来研究将为覆盖特定信号通路的功能提供新的分子线索。与此同时,利用这一技术部门的知识将是在设计酵母衍生产品领域开发创新技术的机会。•酵母细胞在无水状态下表现出显著的结构和功能变化。•脱水导致细胞骨架重组、膜改变和细胞质凝聚。•在酵母的核糖体水平上,缺氧导致蛋白质聚集和翻译减少。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Applied Microbiology and Biotechnology
Applied Microbiology and Biotechnology 工程技术-生物工程与应用微生物
CiteScore
10.00
自引率
4.00%
发文量
535
审稿时长
2 months
期刊介绍: Applied Microbiology and Biotechnology focusses on prokaryotic or eukaryotic cells, relevant enzymes and proteins; applied genetics and molecular biotechnology; genomics and proteomics; applied microbial and cell physiology; environmental biotechnology; process and products and more. The journal welcomes full-length papers and mini-reviews of new and emerging products, processes and technologies.
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