Recent advances in pyrazolo[3,4-b]pyridine chemistry: synthesis techniques and biological activity.

IF 3.9 2区化学 Q2 CHEMISTRY, APPLIED

Molecular Diversity Pub Date : 2025-06-25 DOI:10.1007/s11030-025-11231-5

Anhar Abdel-Aziem, Sawsan A Fouad

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引用次数: 0

Abstract

In recent years, attention has been drawn to pyrazolo[3,4-b] pyridine and its derivatives due to their substantial pharmacological activities such as antidepressant, anticancer, antiviral, antifungal, antioxidant, anticoagulant, anti-Alzheimer, and antimicrobial. Besides their medicinal uses, they act as herbicides, fungicides, and are also used as agrochemicals, inhibitors for a wide range of kinases, and fibroblast growth factor receptors. Additionally, pyrazolo[3,4-b] pyridines are used in developing organic materials for different applications such as chemosensors and corrosion inhibitors for mild steel. This review aims to provide an in-depth overview of the latest advancements regarding synthetic routes, reactions, and biological importance of pyrazolo [3,4-b] pyridine during 2019-2025 which will be a useful resource for interested researchers engaged in this area. The synthetic methodologies focus on metal-catalyst, nanocatalyst, microwave-assisted synthesis, multicomponent reactions, and other green chemistry approaches. Emphasizing the significance of these scaffolds in drug discovery and medicinal chemistry, new developments and future directions in the design of innovative pyrazolo[3,4-b]pyridine-based therapies are also covered.

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吡唑[3,4-b]吡啶化学研究进展：合成技术及生物活性。

近年来，吡唑罗[3,4-b]吡啶及其衍生物因其具有抗抑郁、抗癌、抗病毒、抗真菌、抗氧化、抗凝血、抗阿尔茨海默病和抗菌等药理作用而备受关注。除了药用外，它们还可以作为除草剂、杀菌剂，也可用作农用化学品、多种激酶的抑制剂和成纤维细胞生长因子受体。此外，pyrazolo[3,4-b]吡啶被用于开发不同应用的有机材料，如化学传感器和低碳钢的缓蚀剂。本文综述了2019-2025年吡唑[3,4-b]吡啶的合成路线、反应及其生物学意义等方面的最新进展，为相关研究人员提供参考。合成方法侧重于金属催化剂、纳米催化剂、微波辅助合成、多组分反应和其他绿色化学方法。强调这些支架在药物发现和药物化学中的重要意义，并介绍了新型吡唑[3,4-b]吡啶类药物设计的新进展和未来发展方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Molecular Diversity 化学-化学综合

CiteScore

7.30

自引率

7.90%

发文量

219

审稿时长

2.7 months

期刊介绍： Molecular Diversity is a new publication forum for the rapid publication of refereed papers dedicated to describing the development, application and theory of molecular diversity and combinatorial chemistry in basic and applied research and drug discovery. The journal publishes both short and full papers, perspectives, news and reviews dealing with all aspects of the generation of molecular diversity, application of diversity for screening against alternative targets of all types (biological, biophysical, technological), analysis of results obtained and their application in various scientific disciplines/approaches including: combinatorial chemistry and parallel synthesis; small molecule libraries; microwave synthesis; flow synthesis; fluorous synthesis; diversity oriented synthesis (DOS); nanoreactors; click chemistry; multiplex technologies; fragment- and ligand-based design; structure/function/SAR; computational chemistry and molecular design; chemoinformatics; screening techniques and screening interfaces; analytical and purification methods; robotics, automation and miniaturization; targeted libraries; display libraries; peptides and peptoids; proteins; oligonucleotides; carbohydrates; natural diversity; new methods of library formulation and deconvolution; directed evolution, origin of life and recombination; search techniques, landscapes, random chemistry and more;