Controlled Release of Minoxidil through Hydrogel Cross-Linking to Treat Androgenetic Alopecia.

IF 5.4 2区 医学 Q2 MATERIALS SCIENCE, BIOMATERIALS
Leo L Wang, Spencer Tuohy, Elaine Kim, Arben Nace, Karen L Xu, Ruifeng Yang, Ying Zheng, George Cotsarelis
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Abstract

Minoxidil is the only FDA approved topical treatment for androgenetic alopecia, which is male- or female-pattern hair loss. However, its use is limited by its efficacy and tolerability. Here, we describe a novel bioengineered approach to improve local delivery to the skin. We showed that Schiff bases form between the diamines of minoxidil and aldehyde-modified hyaluronic acid, leading to cross-linking and formation of injectable hydrogels. Hydrogels exhibited tunable release of minoxidil over 6 weeks in vitro with induction of hair growth in vivo in a mouse model after intradermal injection. To improve delivery, hydrogels were fabricated into hydrogel-forming microneedle patches, which allowed controlled, precise, and uniform delivery of minoxidil into skin. Through our approach, we formed highly mechanically robust microneedle patches with heights of 600 or 800 μm with sufficient mechanical strength to penetrate human skin. Minoxidil hydrogel microneedle patches similarly led to anagen induction in a mouse model. Our technology represents a promising new approach to improve minoxidil use and patient outcomes in androgenetic alopecia.

米诺地尔水凝胶交联控释治疗雄激素性脱发。
米诺地尔是FDA批准的唯一治疗雄激素性脱发的药物,雄激素性脱发是男性或女性的脱发。然而,它的使用受到其功效和耐受性的限制。在这里,我们描述了一种新的生物工程方法来改善皮肤的局部递送。我们发现在米诺地尔的二胺和醛修饰的透明质酸之间形成希夫碱,导致交联并形成可注射的水凝胶。在皮内注射后,水凝胶在体外6周内可调节米诺地尔的释放,并在小鼠模型中诱导毛发生长。为了改善给药效果,将水凝胶制成水凝胶形成的微针贴片,使米诺地尔能够被控制、精确和均匀地递送到皮肤中。通过我们的方法,我们形成了高度为600或800 μm的高度机械坚固的微针贴片,具有足够的机械强度穿透人体皮肤。米诺地尔水凝胶微针贴片在小鼠模型中同样导致了生长原诱导。我们的技术代表了一种有希望的新方法来改善米诺地尔的使用和雄激素性脱发的患者预后。
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来源期刊
ACS Biomaterials Science & Engineering
ACS Biomaterials Science & Engineering Materials Science-Biomaterials
CiteScore
10.30
自引率
3.40%
发文量
413
期刊介绍: ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture
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