Systematic Review of Ultrasound Diagnostic Accuracy for Senile Calcified Valvular Heart Disease

IF 1.4 4区医学 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques Pub Date : 2025-06-25 DOI:10.1111/echo.70236

Yuanhong Huang, Jinfeng Wan, Yuling Duan, Xun Guo, Min Huang

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引用次数: 0

Abstract

Objective

To systematically assess the diagnostic accuracy of ultrasound for the detection and evaluation of senile calcified valvular heart disease (SCVD).

Methods

Databases including Web of Science, PubMed, Cochrane Library, Embase, Chinese Biomedical Literature Database (CBM), China National Knowledge Infrastructure (CNKI), and Wanfang and China Science and Technology Journal Database (CQVIP) were systematically queried for studies pertaining to ultrasound in the diagnosis of SCVD from inception to March 2024. Two independent reviewers conducted literature screening, data extraction, and assessment of bias risk for the included studies. Following eligibility screening, a total of 12 papers were included for data extraction and descriptive analysis. Subsequently, meta-analysis was performed using Stata 16.0 software.

Results

A total of 12 studies were finally included. The pooled sensitivity of ultrasound was 0.95 (95% CI = 0.93–0.97), specificity was 0.96 (95% CI = 0.93–0.97), positive likelihood ratio (PLR) was 21.89 (95% CI = 13.27–36.13), negative likelihood ratio (NLR) was 0.05 (95% CI = 0.03–0.07) and diagnostic odds ratio (DOR) and area under the summary receiver operating characteristic curve (AUC) were 453.19 (95% CI = 236.57–868.16) and 0.99 (95% CI: 0.97–0.99), respectively. Sensitivity analysis was carried out after each study was excluded one by one, and the results showed that pooled sensitivity and specificity had no significant change, indicating that the stability of the meta-analysis results was excellent.

Conclusions

Our findings suggest that ultrasound demonstrates high accuracy in diagnosing SCVD, although it does not completely eliminate the possibility of misdiagnosis or missed diagnosis. This study systematically assesses the precision of ultrasound in diagnosing SCVD, offering valuable insights for clinical application.

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老年钙化瓣膜病超声诊断准确性的系统评价

目的系统评价超声对老年性钙化瓣膜性心脏病（SCVD）的诊断准确性。方法系统查询Web of Science、PubMed、Cochrane Library、Embase、中国生物医学文献数据库（CBM）、中国知网（CNKI）、万方和中国科技期刊数据库（CQVIP）等数据库自建库至2024年3月超声诊断SCVD的相关研究。两名独立审稿人对纳入的研究进行了文献筛选、数据提取和偏倚风险评估。经过资格筛选，共纳入12篇论文进行数据提取和描述性分析。随后，采用Stata 16.0软件进行meta分析。结果最终纳入12项研究。超声的综合敏感性为0.95 (95% CI = 0.93-0.97)，特异性为0.96 (95% CI = 0.93-0.97)，阳性似然比（PLR）为21.89 (95% CI = 13.27-36.13)，阴性似然比（NLR）为0.05 (95% CI = 0.03-0.07)，诊断优势比（DOR）和总受者工作特征曲线下面积（AUC）分别为453.19 （95% CI = 236.57-868.16）和0.99 （95% CI: 0.97-0.99）。逐一排除各研究后进行敏感性分析，结果显示合并敏感性和特异性均无显著变化，说明meta分析结果的稳定性很好。结论超声对SCVD的诊断具有较高的准确性，但不能完全消除误诊或漏诊的可能性。本研究系统评估超声诊断SCVD的准确性，为临床应用提供有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Echocardiography-A Journal of Cardiovascular Ultrasound and Allied Techniques 医学-心血管系统

CiteScore

2.40

自引率

6.70%

发文量

211

审稿时长

3-6 weeks

期刊介绍： Echocardiography: A Journal of Cardiovascular Ultrasound and Allied Techniques is the official publication of the International Society of Cardiovascular Ultrasound. Widely recognized for its comprehensive peer-reviewed articles, case studies, original research, and reviews by international authors. Echocardiography keeps its readership of echocardiographers, ultrasound specialists, and cardiologists well informed of the latest developments in the field.