Effects of Essential Oils in the Treatment of Acute Rhinosinusitis: A Systematic Review

IF 1.7 4区医学 Q2 OTORHINOLARYNGOLOGY

Laryngoscope Investigative Otolaryngology Pub Date : 2025-06-25 DOI:10.1002/lio2.70189

Christina M. Matl, Wooyoung Jang, Jordan R. Salley, Callie L. Fort, Joshua C. Demke, Phat Tran, James C. Wang

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Abstract

Objective

Basic science studies have shown that essential oils have antibacterial and anti-inflammatory effects in the nasal mucosa. However, clinical studies examining the effect of essential oils on patient outcomes are limited. The aim of this systematic review is to evaluate the patient outcomes following treatment of acute rhinosinusitis with essential oils.

Methods

PubMed, Ovid, Cochrane, and Embase computerized searches were performed to include results published up to December 2023. Two independent reviewers (C.M.M. and W.J.) conducted data extraction following a predetermined protocol, with any discrepancies reviewed by the senior author (J.C.W.).

Results

Five RCTs investigated the treatment of rhinosinusitis with essential oils in capsule form. Essential oils included in the studies were Cineole, Myrtol (ELOM-080), Sinupret (BNO 1016), and Tavipec. Significant improvements in rhinological symptoms were seen in Cinole compared to placebo, Cinole compared to an herbal compound similar in composition to Sinupret, Tavipec compared to placebo, and ELOM-080 compared to placebo. Outcome measures included nasal obstruction, nasal drainage, facial pressure, headache, fatigue, and fever. Little difference in patient-reported rhinological symptom improvement was seen in ELOM-080 compared to BNO 1016 using a 5-point Likert Scale. Minimal adverse effects were observed in patients treated with essential oils with the most common adverse effect being mild gastrointestinal upset.

Conclusion

Patients using essential oils reported improvement in acute rhinosinusitis symptoms in all studies reviewed, despite differences in methodology and outcome measures. These improvements were statistically significant in all the studies.

Level of Evidence

Level 1 based on “The Oxford 2011 Levels of Evidence”.

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精油治疗急性鼻窦炎的疗效：系统综述

目的基础科学研究表明，精油对鼻黏膜具有抗菌和抗炎作用。然而，检查精油对患者预后影响的临床研究是有限的。本系统综述的目的是评估用精油治疗急性鼻窦炎的患者预后。方法对PubMed、Ovid、Cochrane和Embase进行计算机检索，包括截至2023年12月发表的结果。两位独立审稿人（C.M.M.和W.J.）按照预先确定的方案进行数据提取，任何差异由资深作者（J.C.W.）审查。结果5项随机对照试验探讨了精油胶囊治疗鼻窦炎的疗效。研究中包括的精油有桉树脑、桃金娘酚（ELOM-080）、辛奴普雷特（BNO 1016）和塔维佩克。与安慰剂相比，Cinole在鼻部症状方面有显著改善，与与Sinupret成分相似的草药化合物相比，与Tavipec相比，与安慰剂相比，与ELOM-080相比，Cinole在鼻部症状方面有显著改善。结果测量包括鼻塞、鼻引流、面压、头痛、疲劳和发热。使用5点李克特量表，与BNO 1016相比，ELOM-080患者报告的鼻症状改善差异不大。在用精油治疗的患者中观察到最小的不良反应，最常见的不良反应是轻微的胃肠道不适。结论：在所有研究中，使用精油的患者报告急性鼻窦炎症状得到改善，尽管方法和结果测量存在差异。这些改善在所有研究中都具有统计学意义。依据“牛津2011年证据水平”的证据水平1级。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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