Norsesquiterpenoids from terrestrial and marine organisms: Chemistry, activity and possible biosynthetic pathways (1963–2024)

IF 3.4 2区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Phytochemistry Pub Date : 2025-06-23 DOI:10.1016/j.phytochem.2025.114592

Tao-Tao Xue , Bao-Long Hou , Meng-Meng Yuan , Zhi-Shu Tang , Hong-Bo Xu

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Abstract

Norsesquiterpenoids are naturally occurring carbon-reduced derivatives of sesquiterpenoids that are biosynthesised according to the isoprene rule of Ruzicka. Norsesquiterpenoids have attracted considerable interest from chemists and biologists because of their distinct structural characteristics and biological activity. Numerous norsesquiterpenoids with novel carbon skeletons have been reported. Their diverse structures are linked to various potent biological activities, including anti-inflammatory, anti-microbial, anti-viral, anti-oxidant, anti-Alzheimer, hypoglycaemic and cytotoxic. This review provides a comprehensive summary of 693 natural norsesquiterpenoids discovered in plants, fungi, marine organisms and microorganisms between 1963 and 2024, focussing on their identification, bioactivities and biosynthesis. The review also provides a brief overview of the biosynthesis of norsesquiterpenoids. In addition, several recommendations are proposed for future research. This review aims to serve as a useful reference for the development of natural norsesquiterpenoids and to provide beneficial guidance for the application of these health-related compounds and their source plants in pharmaceuticals, functional foods, cosmetics and agriculture.

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来自陆地和海洋生物的去倍半萜类化合物：化学、活性和可能的生物合成途径（1963-2024）

去倍半萜类化合物是天然存在的倍半萜类化合物的碳还原衍生物，根据Ruzicka异戊二烯规则进行生物合成。去甲倍半萜类化合物因其独特的结构特征和生物活性而引起了化学家和生物学家的极大兴趣。许多具有新型碳骨架的北倍半萜类化合物已被报道。它们的不同结构与各种有效的生物活性有关，包括抗炎、抗微生物、抗病毒、抗氧化、抗阿尔茨海默病、降糖和细胞毒性。本文综述了1963年至2024年在植物、真菌、海洋生物和微生物中发现的693种天然去甾倍半萜类化合物，重点介绍了它们的鉴定、生物活性和生物合成。本文还简要介绍了去甲倍半萜类化合物的生物合成。最后，对今后的研究提出了几点建议。本文旨在为天然去甲倍半萜类化合物的开发提供有益的参考，并为这些与健康相关的化合物及其来源植物在医药、功能食品、化妆品和农业中的应用提供有益的指导。

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来源期刊

Phytochemistry 生物-植物科学

CiteScore

6.40

自引率

7.90%

发文量

443

审稿时长

39 days

期刊介绍： Phytochemistry is a leading international journal publishing studies of plant chemistry, biochemistry, molecular biology and genetics, structure and bioactivities of phytochemicals, including ''-omics'' and bioinformatics/computational biology approaches. Phytochemistry is a primary source for papers dealing with phytochemicals, especially reports concerning their biosynthesis, regulation, and biological properties both in planta and as bioactive principles. Articles are published online as soon as possible as Articles-in-Press and in 12 volumes per year. Occasional topic-focussed special issues are published composed of papers from invited authors.