Biosafety considerations triggered by genome-editing technologies

IF 3.5 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH
Xinxin Li , Yuanjiao Gao , Ziyu Zhang , Wen Deng , Weihua Cao , Xin Wei , Zixuan Gao , Linmei Yao , Shuojie Wang , Yao Xie , Minghui Li
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引用次数: 0

Abstract

Since the discovery of the double helix structure of deoxyribonucleic acid (DNA), significant progress has been made in engineering technologies such as gene analysis and editing, greatly promoting the development of biomedical research and clinical applications. In recent years, the rapid development of genome-editing technologies, especially the clustered regularly interspaced short palindromic repeats-associated protein 9 (CRISPR-Cas9) system, have brought unprecedented opportunities for biomedical research and clinical applications. However, with the widespread application of genome-editing technologies, biosafety issues have gradually attracted the attention of the scientific community and the public. Potential risks such as off-target effects, genomic instability, and ethical and legal issues need to be taken seriously, and their safety and effectiveness in clinical applications still require further verification. This review summarizes the current status and potential risks of gene editing technologies in the medical field and discusses how to ensure its safe application through policies, regulations, and technical means. Through in-depth exploration of these issues, we hope to provide a comprehensive perspective for the scientific community, policy makers, and the public to promote the safe and responsible application of genome-editing technologies.
基因组编辑技术引发的生物安全问题
自脱氧核糖核酸(DNA)双螺旋结构的发现以来,基因分析和编辑等工程技术取得了重大进展,极大地促进了生物医学研究和临床应用的发展。近年来,基因组编辑技术的快速发展,特别是聚集规则间隔短回文重复序列相关蛋白9 (CRISPR-Cas9)系统,为生物医学研究和临床应用带来了前所未有的机遇。然而,随着基因组编辑技术的广泛应用,生物安全问题逐渐引起了科学界和公众的关注。脱靶效应、基因组不稳定性、伦理和法律问题等潜在风险需要认真对待,其临床应用的安全性和有效性仍需进一步验证。本文综述了基因编辑技术在医学领域的现状和潜在风险,并探讨了如何通过政策、法规和技术手段确保其安全应用。我们希望通过对这些问题的深入探讨,为科学界、政策制定者和公众提供一个全面的视角,促进基因组编辑技术的安全、负责任的应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biosafety and Health
Biosafety and Health Medicine-Infectious Diseases
CiteScore
7.60
自引率
0.00%
发文量
116
审稿时长
66 days
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