Beneficial role of GZMK+CD8+ T cells in neurodegeneration

IF 27.6 1区医学 Q1 IMMUNOLOGY

Nature Immunology Pub Date : 2025-06-25 DOI:10.1038/s41590-025-02209-4

引用次数: 0

Abstract

We identify a clonally expanded subset of granzyme K-expressing CD8+ T cells that establish residency in the central nervous system, where they target microglia and help to control the spread of pathogenic phosphorylated tau (pTau) — a hallmark of Alzheimer's disease and other tauopathies. This CD8+ T cell subset is also found in human brains with pTau lesions.

Abstract Image

查看原文本刊更多论文

GZMK+CD8+ T细胞在神经退行性变中的有益作用

我们鉴定了表达颗粒酶k的CD8+ T细胞的克隆扩增亚群，它们在中枢神经系统中建立了驻留，在那里它们靶向小胶质细胞并帮助控制致病性磷酸化tau （pTau）的传播- pTau是阿尔茨海默病和其他tau病的标志。这种CD8+ T细胞亚群也存在于pTau病变的人脑中。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Nature Immunology 医学-免疫学

CiteScore

40.00

自引率

2.30%

发文量

248

审稿时长

4-8 weeks

期刊介绍： Nature Immunology is a monthly journal that publishes the highest quality research in all areas of immunology. The editorial decisions are made by a team of full-time professional editors. The journal prioritizes work that provides translational and/or fundamental insight into the workings of the immune system. It covers a wide range of topics including innate immunity and inflammation, development, immune receptors, signaling and apoptosis, antigen presentation, gene regulation and recombination, cellular and systemic immunity, vaccines, immune tolerance, autoimmunity, tumor immunology, and microbial immunopathology. In addition to publishing significant original research, Nature Immunology also includes comments, News and Views, research highlights, matters arising from readers, and reviews of the literature. The journal serves as a major conduit of top-quality information for the immunology community.