Changes in Helicobacter pylori Status in Patients Who Underwent Partial Gastrectomy for Gastric Cancer Therapy.

Abstract

The role of Helicobacter pylori eradication in patients with gastric cancer (GC) undergoing gastrectomy remains unknown because current evidence is limited. This retrospective study investigated H. pylori infection status, eradication therapy, and success rates based on surgical methods. A total of 2827 patients underwent gastrectomy for GC; 1510 (53.4%) tested positive for H. pylori, 1121 (39.7%) tested negative, and 196 (6.9%) were not tested. Among H. pylori-positive patients, 765 underwent eradication therapy, with treatment failure in 36 patients. Among the untreated patients, H. pylori was observed to have spontaneously disappeared by follow-up in 206 of 745 patients. The proportion of patients with spontaneous negative conversion was higher in the proximal and pylorus-preserving gastrectomy groups than in the distal gastrectomy group. However, no difference was observed in the failure rate of eradication therapy based on the surgical method used.