Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing Enterobacterales infections in hospitalized adults.

IF 3.4 Q2 INFECTIOUS DISEASES

Therapeutic Advances in Infectious Disease Pub Date : 2025-06-20 eCollection Date: 2025-01-01 DOI:10.1177/20499361251338017

Andy Lim, Terrence McSweeney, Phyu M Thwe, Mei H Chang, Hongkai Bao, Philip Lee, Kelsie Cowman, Priya Nori, Yi Guo

{"title":"Selective reporting of antibiotic susceptibility testing results: a retrospective evaluation of a nudging strategy to improve antibiotic prescribing for ampC-producing Enterobacterales infections in hospitalized adults.","authors":"Andy Lim, Terrence McSweeney, Phyu M Thwe, Mei H Chang, Hongkai Bao, Philip Lee, Kelsie Cowman, Priya Nori, Yi Guo","doi":"10.1177/20499361251338017","DOIUrl":null,"url":null,"abstract":"Background: Moderate-risk ampC beta-lactamase-producing Enterobacterales (HECK-Yes organisms) render many beta-lactams ineffective.Objective: This study evaluates selective reporting (SR) of antimicrobial susceptibility testing (AST) results to improve antibiotic prescribing for these infections.Design: A retrospective quasi-experimental study evaluating patients before and after the implementation of SR.Methods: SR of AST results for HECK-Yes organisms was implemented at a 1500-bed medical center. A retrospective study compared antibiotic prescribing before and after implementation in patients with positive blood or respiratory cultures.Results: Fifty patients were included in both pre- and post-implementation groups with similar baseline characteristics. Post-implementation, appropriate antibiotics within 24 h of AST report increased by 24% (62% pre vs 86% post, p = 0.01). A total of 30-day mortality, clinical success, and microbiological failure rates were similar between groups.Conclusion: SR improved appropriate antibiotic prescribing for moderate-risk ampC-producing Enterobacterales (e.g., HECK-Yes) infections.","PeriodicalId":46154,"journal":{"name":"Therapeutic Advances in Infectious Disease","volume":"12 ","pages":"20499361251338017"},"PeriodicalIF":3.4000,"publicationDate":"2025-06-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12181692/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Therapeutic Advances in Infectious Disease","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1177/20499361251338017","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q2","JCRName":"INFECTIOUS DISEASES","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Moderate-risk ampC beta-lactamase-producing Enterobacterales (HECK-Yes organisms) render many beta-lactams ineffective.

Objective: This study evaluates selective reporting (SR) of antimicrobial susceptibility testing (AST) results to improve antibiotic prescribing for these infections.

Design: A retrospective quasi-experimental study evaluating patients before and after the implementation of SR.

Methods: SR of AST results for HECK-Yes organisms was implemented at a 1500-bed medical center. A retrospective study compared antibiotic prescribing before and after implementation in patients with positive blood or respiratory cultures.

Results: Fifty patients were included in both pre- and post-implementation groups with similar baseline characteristics. Post-implementation, appropriate antibiotics within 24 h of AST report increased by 24% (62% pre vs 86% post, p = 0.01). A total of 30-day mortality, clinical success, and microbiological failure rates were similar between groups.

Conclusion: SR improved appropriate antibiotic prescribing for moderate-risk ampC-producing Enterobacterales (e.g., HECK-Yes) infections.

查看原文本刊更多论文

选择性报告抗生素敏感性试验结果：对促进住院成人产ampc肠杆菌感染的抗生素处方的回顾性评估。

背景：中等风险ampC -内酰胺酶产生肠杆菌（HECK-Yes生物体）使许多-内酰胺无效。目的：评价抗菌药物敏感性试验（AST）结果的选择性报告（SR），以改进此类感染的抗生素处方。设计：一项回顾性准实验研究，评估患者在实施SR前后的情况。方法：在某医疗中心1500张床位对HECK-Yes生物体的AST结果进行SR。一项回顾性研究比较了血液或呼吸培养阳性患者实施抗生素处方前后的差异。结果：50例患者被纳入实施前和实施后两组，基线特征相似。实施后，AST报告24 h内适宜使用抗生素的患者增加24%（实施前62% vs实施后86%，p = 0.01）。总的30天死亡率、临床成功率和微生物失败率在两组之间相似。结论：SR改善了中等风险产ampc肠杆菌（如HECK-Yes）感染的适当抗生素处方。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊