Mapping the Evolution of Solid Organ Xenotransplantation Research:A Systematic Review.

IF 3.3 4区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Xenotransplantation Pub Date : 2025-05-01 DOI:10.1111/xen.70058

Ivana Juric, Marc Raynaud, Lea Skoric, Solaf Al-Awadhi, Agathe Truchot, Marta Sablik, Xiaoqian Ma, Kaikai Lv, Huanxi Zhang, Kevin Louis, Nikolina Basic-Jukic, Renaud Tissier, Thierry Hauet, Emanuele Cozzi, Gabriel C Oniscu, Massimo Mangiola, Joseph A Tector, Leonardo V Riella, Jayme E Locke, Didier Samuel, Raphael P H Meier, Muhammad M Mohiuddin, Robert A Montgomery, Alexandre Loupy

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引用次数: 0

Abstract

Introduction: Xenotransplantation has emerged as a promising solution to organ shortage, generating numerous publications. However, no studies have analyzed the research dynamics of xenotransplantation research. We aimed to systematically assess xenotransplantation publication activity.

Methods: A systematic literature search was conducted up to November 22, 2024. Studies on xenotransplantation of solid organs and islets of Langerhans from animals to humans, or perfusion with human blood or its derivatives were included. Publication information, publishing journal, publication type, organ, donor species, and topics studied were extracted.

Results: Of 2944 publications, 706 met inclusion criteria: 41.2% original articles, 41.1% reviews, 14.2% publications without original data, 1.6% case reports, 1.3% research letters, 0.6% systematic reviews/meta-analyses. Publication activity displayed two peaks: in the 1990s, driven by the gene editing advancements, and in the early 2020s, following the first pig-to-human transplantation. The top five publishing countries were the USA with (48.2%), Germany (10.2%), UK (5.4%), Sweden (4.8%), and China (4.2%). Xenotransplantation journal accounted for 19.7% of publications, transplantation journals for 27.6%, and general medical journals for 5.4%. Islets of Langerhans were studied in 23.1% of studies, and the most studied organs were heart (21.2%), followed by kidney (17.1%), liver (12.2%), and lung (6.2%). The most represented thematic groups were rejection, immune mechanisms, overall challenges, gene editing, current research, and prospects.

Conclusion: This first systematic assessment of xenotransplantation research highlights its growing global interest and evolving focus areas. The low proportion of publications with original data underscores the need for more original research. Limited representation in general medical journals highlights the importance of engaging a broader audience as clinical trials approach.

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实体器官异种移植研究的发展：系统回顾。

异种移植已经成为解决器官短缺的一个有希望的解决方案，产生了许多出版物。然而，目前还没有研究分析异种移植研究的动态。我们的目的是系统地评估异种移植的出版物活动。方法：系统检索截至2024年11月22日的文献。包括动物实体器官和朗格汉斯胰岛异种移植给人，或灌注人血或其衍生物的研究。提取出版信息、出版期刊、出版类型、器官、供体种类、研究课题。结果：在2944篇出版物中，706篇符合纳入标准：41.2%为原创文章，41.1%为综述，14.2%为无原始数据的出版物，1.6%为病例报告，1.3%为研究信函，0.6%为系统综述/元分析。出版活动出现了两个高峰：在上世纪90年代，由基因编辑技术的进步推动；以及在21世纪20年代初，在第一次猪到人的移植之后。排名前五的出版国家分别是美国（48.2%）、德国（10.2%）、英国（5.4%）、瑞典（4.8%）和中国（4.2%）。异种移植期刊占19.7%，移植期刊占27.6%，普通医学期刊占5.4%。23.1%的研究研究了朗格汉斯胰岛，研究最多的器官是心脏（21.2%），其次是肾脏（17.1%）、肝脏（12.2%）和肺（6.2%）。最具代表性的主题组是排斥、免疫机制、总体挑战、基因编辑、当前研究和前景。结论：这是对异种移植研究的首次系统评估，突出了其日益增长的全球兴趣和不断发展的重点领域。具有原始数据的出版物的低比例强调了对更多原始研究的需求。在普通医学期刊上的有限代表性突出了临床试验方法吸引更广泛受众的重要性。

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来源期刊

Xenotransplantation 医学-医学：研究与实验

CiteScore

6.80

自引率

15.40%

发文量

审稿时长

>12 weeks

期刊介绍： Xenotransplantation provides its readership with rapid communication of new findings in the field of organ and tissue transplantation across species barriers.The journal is not only of interest to those whose primary area is xenotransplantation, but also to veterinarians, microbiologists and geneticists. It also investigates and reports on the controversial theological, ethical, legal and psychological implications of xenotransplantation.