Plasmacytoid dendritic cell proliferations, malignant histiocytic (macrophage/dendritic cell) neoplasms and follicular dendritic cell neoplasms: report from the 2024 Joint CSHP/EA4HP/SH workshop.

IF 3.4 3区 医学 Q1 PATHOLOGY
Caoimhe Egan, Sophie Song, Wei-Ping Liu, Zhe Wang, Wenbin Xiao, John K C Chan, Stefan Dirnhofer, Falko Fend, John R Goodlad, Xiaoqiu Li, Robert Lorsbach, Jean-Francois Emile
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Abstract

Histiocytic and dendritic cell neoplasms of hematopoietic origin are derived from or show differentiation towards the cells of the mononuclear phagocyte system. Plasmacytoid dendritic cell proliferations/neoplasms include mature plasmacytoid dendritic cell proliferations identified in the context of a defined myeloid neoplasm and blastic plasmacytoid dendritic cell neoplasm, an aggressive tumor with a poor outcome. Malignant histiocytic (macrophage/dendritic cell) neoplasms occur de novo or in the setting of another hematological malignancy, typically "transdifferentiated" from associated lymphoid neoplasia. Recurrent alterations in the MAPK pathway have been shown to have a key role in their pathogenesis. Neoplasms derived from follicular dendritic cells and fibroblastic reticular cells originate from a mesenchymal precursor. The major entities in this group include follicular dendritic sarcoma, which has recently been shown to harbor recurrent alterations in NF-κB pathway genes, and EBV positive inflammatory follicular dendritic cell sarcoma/tumor, a rare lesion with an inflammatory pseudotumor-like morphology and association with EBV infection. At the joint Workshop of the Chinese Society of Hematopathology (CSHP), the European Association for Haematopathology (EA4HP) and the Society for Hematopathology (SH) on histiocytic/dendritic cell proliferations, neoplasms, and their mimics in Hefei, China, April 2024, there were 16 cases submitted to session 3 on plasmacytoid dendritic cell proliferations and neoplasms, and a total of 42 submissions to session 4 on malignant histiocytic and dendritic cell neoplasms, including stroma-derived neoplasms. A summary of the findings and conclusions arising from discussion of the workshop cases are presented in this report.

浆细胞样树突状细胞增殖、恶性组织细胞(巨噬细胞/树突状细胞)肿瘤和滤泡树突状细胞肿瘤:来自2024年CSHP/EA4HP/SH联合研讨会的报告
造血起源的组织细胞和树突状细胞肿瘤来源于或向单核吞噬细胞系统的细胞分化。浆细胞样树突状细胞增生/肿瘤包括成熟浆细胞样树突状细胞增生,在明确的髓系肿瘤和母浆细胞样树突状细胞肿瘤的背景下确定,这是一种预后不良的侵袭性肿瘤。恶性组织细胞(巨噬细胞/树突状细胞)肿瘤发生于新生或其他血液系统恶性肿瘤,通常与相关淋巴样肿瘤“转分化”。MAPK通路的复发性改变已被证明在其发病机制中起关键作用。来源于滤泡树突状细胞的肿瘤和来源于间充质前体细胞的成纤维网状细胞。这一组的主要肿瘤包括滤泡性树突状肉瘤和EBV阳性炎性滤泡性树突状细胞肉瘤/肿瘤,前者最近被证明具有NF-κB通路基因的复发性改变,后者是一种罕见的炎性假瘤样病变,与EBV感染有关。2024年4月,在中国合肥举行的中国血液病理学会(CSHP)、欧洲血液病理学会(EA4HP)和血液病理学会(SH)关于组织细胞/树突状细胞增殖、肿瘤及其模拟物的联合研讨会上,有16例病例提交给浆细胞样树突状细胞增殖和肿瘤的第3次会议,共有42例病例提交给恶性组织细胞和树突状细胞肿瘤的第4次会议。包括基质源性肿瘤。本报告概述了讨论讲习班案例所产生的调查结果和结论。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Virchows Archiv
Virchows Archiv 医学-病理学
CiteScore
7.40
自引率
2.90%
发文量
204
审稿时长
4-8 weeks
期刊介绍: Manuscripts of original studies reinforcing the evidence base of modern diagnostic pathology, using immunocytochemical, molecular and ultrastructural techniques, will be welcomed. In addition, papers on critical evaluation of diagnostic criteria but also broadsheets and guidelines with a solid evidence base will be considered. Consideration will also be given to reports of work in other fields relevant to the understanding of human pathology as well as manuscripts on the application of new methods and techniques in pathology. Submission of purely experimental articles is discouraged but manuscripts on experimental work applicable to diagnostic pathology are welcomed. Biomarker studies are welcomed but need to abide by strict rules (e.g. REMARK) of adequate sample size and relevant marker choice. Single marker studies on limited patient series without validated application will as a rule not be considered. Case reports will only be considered when they provide substantial new information with an impact on understanding disease or diagnostic practice.
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