Stem cell derived exosome trilogy: an epic comparison of human MSCs, ESCs and iPSCs.

IF 7.1 2区医学 Q1 CELL & TISSUE ENGINEERING

Stem Cell Research & Therapy Pub Date : 2025-06-23 DOI:10.1186/s13287-025-04440-0

Siti Zawiah Abdul Malik, Yugashini Muhilan, Fazlina Nordin, Min Hwei Ng, Jia Xian Law, Siti A M Imran, Izyan Mohd Idris, Gee Jun Tye

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Abstract

Exosomes, containing molecular constituents of their cell of origin, including proteins and nucleic acids, were first discovered in immature red blood cells in 1983. Excellent intercell communication can be achieved by shuttling these various molecules between cells. Stem cell-derived exosomes (SC-Exos) contain paracrine-soluble factors that play important roles in tissue development, homeostasis, and regeneration. This paracrine activity of SC-Exos has been found to be a predominant mechanism by which stem cell-based therapies mediate their effects on degenerative, autoimmune and/or inflammatory diseases. Compared to other types of stem cells, human embryonic stem cells (hESCs), human induced pluripotent stem cells (hiPSCs), human mesenchymal stem cells (hMSCs) are the most popular because of their efficient immunomodulatory effects. The advantages and disadvantages of using exosomes isolated from the stem cell trio for therapeutic applications are further discussed in this review.

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干细胞衍生外泌体三部曲：人类MSCs， ESCs和iPSCs的史诗比较。

外泌体是1983年首次在未成熟的红细胞中发现的，它含有细胞起源的分子成分，包括蛋白质和核酸。通过在细胞间穿梭这些不同的分子，可以实现良好的细胞间通讯。干细胞来源的外泌体（SC-Exos）含有旁分泌可溶性因子，在组织发育、体内平衡和再生中起重要作用。SC-Exos的这种旁分泌活性已被发现是干细胞治疗介导其对退行性、自身免疫性和/或炎症性疾病的作用的主要机制。与其他类型的干细胞相比，人胚胎干细胞（hESCs）、人诱导多能干细胞（hiPSCs）、人间充质干细胞（hMSCs）因其有效的免疫调节作用而最受欢迎。本文将进一步讨论从干细胞三重奏中分离的外泌体用于治疗应用的优点和缺点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cell Research & Therapy CELL BIOLOGY-MEDICINE, RESEARCH & EXPERIMENTAL

CiteScore

13.20

自引率

8.00%

发文量

525

审稿时长

1 months

期刊介绍： Stem Cell Research & Therapy serves as a leading platform for translational research in stem cell therapies. This international, peer-reviewed journal publishes high-quality open-access research articles, with a focus on basic, translational, and clinical research in stem cell therapeutics and regenerative therapies. Coverage includes animal models and clinical trials. Additionally, the journal offers reviews, viewpoints, commentaries, and reports.