Association Between High-Risk Human Papillomavirus Prevalence and Circumcision Status Among Sexually Experienced Adult Men, 2013 to 2016, United States.

IF 1.7 4区 医学 Q3 INFECTIOUS DISEASES
Sexually transmitted diseases Pub Date : 2025-11-01 Epub Date: 2025-06-23 DOI:10.1097/OLQ.0000000000002207
Rayleen M Lewis, Sarah K Brewer, Julia W Gargano, Troy D Querec, Elizabeth R Unger, Lauri E Markowitz
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引用次数: 0

Abstract

Background: Randomized control trials in sub-Saharan countries found that male circumcision may prevent high-risk human papillomavirus (HR-HPV) acquisition. Using 2013-2016 National Health and Nutrition Examination Survey data, we explored the association between circumcision and HR-HPV among sexually experienced 18- to 59-year-old men.

Methods: Self-collected penile specimens were tested for HPV DNA. We estimated weighted HR-HPV prevalence (positivity to ≥1 HR type: HPV-16/18/31/33/35/39/45/51/52/56/58/59/66/68) by circumcision status. The association between circumcision and HR-HPV was assessed using multivariable logistic regression models. Effect modification by circumcision on the association between number of lifetime sex partners and HR-HPV was explored.

Results: Overall, 77.7% of men reported being circumcised, with large variation by race/ethnicity and country of birth. High-risk HPV prevalence was significantly higher among circumcised (25.7%) than uncircumcised (20.4%) men; this was attenuated after adjustment for lifetime and new past-year sex partners (adjusted prevalence ratio, 1.10; 95% confidence interval, 0.92-1.32). There was evidence that circumcision modified the association between lifetime partners and HR-HPV, but HR-HPV prevalence increased with increasing number of partners in circumcised and uncircumcised men.

Conclusions: Our observed lack of statistical association between circumcision and HR-HPV may differ from randomized trial results because of the differences between circumcised and uncircumcised men or differences in anatomic site sampled or timing of circumcision.

2013-2016年美国性经历成年男性中高危HPV患病率与包皮环切状况的关系
背景:撒哈拉以南国家的随机对照试验发现,男性包皮环切术可以预防高危人乳头瘤病毒(HR-HPV)的获得。利用2013-2016年全国健康与营养调查数据,我们探讨了18-59岁性经验男性包皮环切术与HR-HPV的关系。方法:自行采集阴茎标本进行HPV DNA检测。我们根据包皮环切状况估计加权HR- hpv患病率(阳性≥1 HR型:HPV16/18/31/33/35/39/45/51/52/56/58/59/66/68)。使用多变量logistic回归模型评估包皮环切术与HR-HPV之间的关系。探讨包皮环切术对终生性伴侣数量与HR-HPV相关性的影响。结果:总体而言,77.7%的男性报告接受了包皮环切术,种族/民族和出生国家差异很大。包皮环切术男性的HR-HPV患病率(25.7%)明显高于未包皮环切术男性(20.4%);调整终生性伴侣和过去一年新的性伴侣后,这种情况减弱(调整患病率:1.10,95%CI: 0.92-1.32)。有证据表明,包皮环切术改变了终身伴侣与HR-HPV之间的关系,但HR-HPV患病率随着包皮环切术和未包皮环切术男性伴侣数量的增加而增加。结论:我们观察到的包皮环切术与HR-HPV之间缺乏统计相关性可能与随机试验结果不同,这可能是由于包皮环切术与未包皮环切术男性之间的差异,或者是解剖部位取样或包皮环切术时间的差异。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Sexually transmitted diseases
Sexually transmitted diseases 医学-传染病学
CiteScore
4.00
自引率
16.10%
发文量
289
审稿时长
3-8 weeks
期刊介绍: ​Sexually Transmitted Diseases, the official journal of the American Sexually Transmitted Diseases Association​, publishes peer-reviewed, original articles on clinical, laboratory, immunologic, epidemiologic, behavioral, public health, and historical topics pertaining to sexually transmitted diseases and related fields. Reports from the CDC and NIH provide up-to-the-minute information. A highly respected editorial board is composed of prominent scientists who are leaders in this rapidly changing field. Included in each issue are studies and developments from around the world.
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