rs928508 of miR-30c-5p is Associated with the Risk of Post-ERCP Pancreatitis.

IF 1.7 4区医学 Q3 GASTROENTEROLOGY & HEPATOLOGY

Pancreas Pub Date : 2025-06-24 DOI:10.1097/MPA.0000000000002527

Yunyun Sun, Xia Li, Liang Chen, Jun Zhang

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引用次数: 0

Abstract

Objective: Endoscopic retrograde cholangiopancreatography (ERCP) is a widely utilized endoscopic technique for the diagnosis and therapy of biliary and pancreatic diseases. It usually leads to different complications including post-ERCP pancreatitis (PEP). This study aimed to evaluate the correlation between miR-30c-5p rs928508 polymorphism and the risk of PEP and to analyze the effect of it on serum miR-30c-5p level.

Methods: Patients with PEP were collected as a case group, while patients without complications were gathered as a control group. miR-30c-5p levels were measured using qRT-PCR, and rs928508 genotyping was performed using the TaqMan method. Logistic regression analysis was used to recognize independent risk factors for PEP.

Results: The case group had significantly lower miR-30c-5p levels, especially in AG/GG genotype carriers. rs928508 was correlated with increased PEP risk under GG vs. AA (OR=2.170, 95%CI=1.118-4.210), AG/GG vs. AA (P=0.032, OR=1.840, 95%CI=1.048-3.231) and G vs. A (P=0.026, OR=1.433, 95%CI=1.043-1.969) models. Meanwhile, AG (OR=33.023, 95%CI=1.026-8.906), GG (OR=3.344, 95%CI=1.070-10.450), and AG/GG (OR=3.138, 95%CI=1.103-8.932) genotypes were correlated with high severity of PEP. Multivariate analysis suggested that drinking (OR=2.091, 95%CI=1.102-3.968), difficult cannulation (OR=2.198, 95%CI=1.301-3.712), pancreatic duct visualization (OR=5.468, 95%CI=2.945-10.151), pancreatic duct stenting history (OR=3.415, 95%CI=1.742-6.693), and AG/GG genotypes of rs928508 (OR=2.137, 95%CI=1.114-4.100) were independent risk factors for PEP onset.

Conclusion: miR-30c-5p rs928508 polymorphism is correlated with an enhanced risk and severity of PEP.

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miR-30c-5p的rs928508与ercp后胰腺炎的风险相关

目的：内镜逆行胰胆管造影（ERCP）是一种广泛应用于胆胰疾病诊断和治疗的内镜技术。它通常会导致不同的并发症，包括ercp后胰腺炎（PEP）。本研究旨在评价miR-30c-5p rs928508多态性与PEP风险的相关性，并分析其对血清miR-30c-5p水平的影响。方法：选取PEP患者为病例组，无并发症患者为对照组。采用qRT-PCR检测miR-30c-5p水平，采用TaqMan方法进行rs928508基因分型。采用Logistic回归分析识别PEP的独立危险因素。结果：病例组的miR-30c-5p水平明显降低，特别是在AG/GG基因型携带者中。rs928508与GG vs AA （OR=2.170, 95%CI=1.118 ~ 4.210）、AG/GG vs AA （P=0.032， OR=1.840, 95%CI=1.048 ~ 3.231）、G vs A （P=0.026， OR=1.433, 95%CI=1.043 ~ 1.969）模型下PEP风险增加相关。AG （OR=33.023, 95%CI=1.026 ~ 8.906）、GG （OR=3.344, 95%CI=1.070 ~ 10.450）和AG/GG （OR=3.138, 95%CI=1.103 ~ 8.932）基因型与PEP高严重程度相关。多因素分析显示，饮酒（OR=2.091, 95%CI=1.102 ~ 3.968）、插管困难（OR=2.198, 95%CI=1.301 ~ 3.712）、胰管显像（OR=5.468, 95%CI=2.945 ~ 10.151）、胰管支架植入史（OR=3.415, 95%CI=1.742 ~ 6.693）、rs928508基因AG/GG型（OR=2.137, 95%CI=1.114 ~ 4.100）是PEP发病的独立危险因素。结论：miR-30c-5p rs928508多态性与PEP的风险和严重程度增加相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Pancreas 医学-胃肠肝病学

CiteScore

4.70

自引率

3.40%

发文量

289

审稿时长

1 months

期刊介绍： Pancreas provides a central forum for communication of original works involving both basic and clinical research on the exocrine and endocrine pancreas and their interrelationships and consequences in disease states. This multidisciplinary, international journal covers the whole spectrum of basic sciences, etiology, prevention, pathophysiology, diagnosis, and surgical and medical management of pancreatic diseases, including cancer.