Trichophyton Quinckeanum: Renaissance of the Mouse Favus Pathogen in Central Germany.

IF 3.1 2区医学 Q1 DERMATOLOGY

Mycoses Pub Date : 2025-06-01 DOI:10.1111/myc.70079

Christin Pelzer, Pietro Nenoff, Daniela Koch, Hanna Muetze, Constanze Krueger, Antonio Cozzio, Silke Uhrlass

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引用次数: 0

Abstract

Background: Trichophyton quinckeanum is a zoophilic dermatophyte causing mouse favus, that was only sporadically detected in Germany for decades. Since 2014, an increasing number of isolates have been found in central Germany, giving rise to dermatophyte skin infections and skin appendix infections like tinea capitis or even kerion Celsi.

Objectives: The goal of this study was to characterize the specific features of dermatophyte infections due to T. quinckeanum.

Methods: We collected the data of 550 isolates of T. quinckeanum from Germany between March 2014 and December 2024 in the laboratory in Mölbis, Germany, in order to identify specific features of the zoophilic dermatophyte infection.

Results: To our knowledge, we present the highest number of cases ever published. Infection rates show a yearly recurring increase in autumn and winter months, whereas infection rates in spring and summer months are typically low. The peak of infections in the current epidemic in central Germany was seen in 2021. Mainly children, teenagers and young adults are affected.

Conclusions: T. quinckeanum has now become a relevant pathogen in Germany and surrounding countries. Even though the current epidemic is in decline, it is to be expected that in the future, infection rates will again correlate with the cyclic mouse population numbers, as they are the main source of infection. Climate change may also play an important role for mouse populations. Transmission to humans typically occurs via an intermediate host like cats (and less likely dogs), which is why pet owners are most at risk.

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昆基毛癣菌：德国中部鼠瘟病菌的复兴。

背景：quinckeanum毛癣菌（Trichophyton quinckeanum）是一种引起小鼠偏爱的嗜兽性皮肤真菌，在德国几十年来仅被零星发现。自2014年以来，在德国中部发现了越来越多的分离株，导致皮肤真菌感染和皮肤阑尾感染，如头癣甚至角膜炎。目的：本研究的目的是表征由T. quinckeanum引起的皮肤真菌感染的具体特征。方法：收集2014年3月至2024年12月在德国Mölbis实验室分离的550株昆克南T. quinckeanum菌株的资料，以确定该嗜兽性皮肤真菌感染的具体特征。结果：据我们所知，我们提出的病例数量是有史以来最多的。在秋季和冬季，感染率每年都在增加，而春季和夏季的感染率通常较低。德国中部当前疫情的感染高峰出现在2021年。受影响的主要是儿童、青少年和年轻人。结论：quinckeanum已成为德国及周边国家的相关病原菌。尽管目前的流行正在下降，但可以预期，在未来，感染率将再次与循环小鼠种群数量相关，因为它们是感染的主要来源。气候变化也可能对老鼠数量起重要作用。传染给人类通常是通过中间宿主，比如猫（不太可能是狗），这就是为什么宠物主人的风险最大。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Mycoses 医学-皮肤病学

CiteScore

10.00

自引率

8.20%

发文量

143

审稿时长

6-12 weeks

期刊介绍： The journal Mycoses provides an international forum for original papers in English on the pathogenesis, diagnosis, therapy, prophylaxis, and epidemiology of fungal infectious diseases in humans as well as on the biology of pathogenic fungi. Medical mycology as part of medical microbiology is advancing rapidly. Effective therapeutic strategies are already available in chemotherapy and are being further developed. Their application requires reliable laboratory diagnostic techniques, which, in turn, result from mycological basic research. Opportunistic mycoses vary greatly in their clinical and pathological symptoms, because the underlying disease of a patient at risk decisively determines their symptomatology and progress. The journal Mycoses is therefore of interest to scientists in fundamental mycological research, mycological laboratory diagnosticians and clinicians interested in fungal infections.