Bilateral radiation-induced squamous cell carcinoma of the external auditory canal: the effect of immunosuppressive therapy.

IF 0.8 4区医学 Q3 OTORHINOLARYNGOLOGY

Journal of Laryngology and Otology Pub Date : 2025-06-24 DOI:10.1017/S0022215125102569

Cole Needham, Jonn Wu, Desmond A Nunez

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Abstract

Background: Squamous cell carcinoma of the external auditory canal is rare, with bilateral cases even rarer. We report the management of a patient with bilateral external auditory canal squamous cell carcinoma related to radiotherapy and immunosuppression.

Case report: A 47-year-old woman with a history of radiotherapy 14 years prior and renal transplantation 6 years prior presented with bilateral external auditory canal squamous cell carcinoma. Squamous cell carcinoma was excised with a purely surgical approach. The two operations included a tympanic membrane graft to preserve hearing on the left side. The patient remains disease-free six months post-op. She uses a bone-conduction hearing aid to good effect on the right side and has mild hearing loss on the left. The operative areas have healed well.

Discussion: The patient's previous radiotherapy and immunosuppression may have contributed to her bilateral external auditory canal squamous cell carcinoma. Preventative positron emission tomography scans have the potential to identify second malignancies early, allowing more conservative treatment plans.

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双侧放射诱导的外耳道鳞状细胞癌：免疫抑制治疗的效果。

背景：外耳道鳞状细胞癌罕见，双侧病例更为罕见。我们报告一例与放疗和免疫抑制相关的双侧外耳道鳞状细胞癌的治疗。病例报告：一名47岁女性，14年前放疗，6年前肾移植，双侧外耳道鳞状细胞癌。鳞状细胞癌采用纯手术切除。这两个手术包括一个鼓膜移植，以保持左侧听力。病人术后6个月无病。她使用骨传导助听器，右侧效果良好，左侧听力略有下降。手术部位愈合良好。讨论：患者以前的放疗和免疫抑制可能是导致双侧外耳道鳞状细胞癌的原因。预防性正电子发射断层扫描有可能及早发现第二种恶性肿瘤，允许更保守的治疗计划。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Laryngology and Otology 医学-耳鼻喉科学

CiteScore

3.20

自引率

11.80%

发文量

593

审稿时长

3-6 weeks

期刊介绍： The Journal of Laryngology & Otology (JLO) is a leading, monthly journal containing original scientific articles and clinical records in otology, rhinology, laryngology and related specialties. Founded in 1887, JLO is absorbing reading for ENT specialists and trainees. The journal has an international outlook with contributions from around the world, relevant to all specialists in this area regardless of the country in which they practise. JLO contains main articles (original, review and historical), case reports and short reports as well as radiology, pathology or oncology in focus, a selection of abstracts, book reviews, letters to the editor, general notes and calendar, operative surgery techniques, and occasional supplements. It is fully illustrated and has become a definitive reference source in this fast-moving subject area. Published monthly an annual subscription is excellent value for money. Included in the subscription is access to the JLO interactive web site with searchable abstract database of the journal archive back to 1887.