{"title":"A Simple and Rapid Fluorescent Sensor Based on MoS<sub>2</sub> Quantum Dots for Dopamine Detection.","authors":"Yunbo Zhao, Fangyuan Yang, Lefa Zhao, Guangda Xu","doi":"10.1007/s10895-025-04413-9","DOIUrl":null,"url":null,"abstract":"<p><p>In this study, molybdenum disulfide quantum dots (MoS<sub>2</sub> QDs) were synthesized via a one-step hydrothermal method, and a simple, rapid fluorescent sensing platform for dopamine (DA) detection was established based on fluorescence quenching. Experimental results demonstrated that DA is oxidized to dopamine quinone under alkaline conditions, leading to fluorescence quenching of MoS<sub>2</sub> QDs through the synergistic effects of inner filter effect (IFE) and electron transfer (ET). The optimized method exhibited a linear response at 434 nm (200-600 µM, R<sup>2</sup> = 0.9980) with a detection limit of 4 µM. The sensor showed high selectivity for DA and was successfully applied to spiked recovery tests in human urine samples, achieving recoveries of 95-104.6%. The stability of MoS<sub>2</sub> QDs, simplicity of preparation, and practical applicability highlight its potential for DA analysis in complex biological samples.</p>","PeriodicalId":15800,"journal":{"name":"Journal of Fluorescence","volume":" ","pages":""},"PeriodicalIF":2.6000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Fluorescence","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1007/s10895-025-04413-9","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMICAL RESEARCH METHODS","Score":null,"Total":0}
引用次数: 0
Abstract
In this study, molybdenum disulfide quantum dots (MoS2 QDs) were synthesized via a one-step hydrothermal method, and a simple, rapid fluorescent sensing platform for dopamine (DA) detection was established based on fluorescence quenching. Experimental results demonstrated that DA is oxidized to dopamine quinone under alkaline conditions, leading to fluorescence quenching of MoS2 QDs through the synergistic effects of inner filter effect (IFE) and electron transfer (ET). The optimized method exhibited a linear response at 434 nm (200-600 µM, R2 = 0.9980) with a detection limit of 4 µM. The sensor showed high selectivity for DA and was successfully applied to spiked recovery tests in human urine samples, achieving recoveries of 95-104.6%. The stability of MoS2 QDs, simplicity of preparation, and practical applicability highlight its potential for DA analysis in complex biological samples.
期刊介绍：
Journal of Fluorescence is an international forum for the publication of peer-reviewed original articles that advance the practice of this established spectroscopic technique. Topics covered include advances in theory/and or data analysis, studies of the photophysics of aromatic molecules, solvent, and environmental effects, development of stationary or time-resolved measurements, advances in fluorescence microscopy, imaging, photobleaching/recovery measurements, and/or phosphorescence for studies of cell biology, chemical biology and the advanced uses of fluorescence in flow cytometry/analysis, immunology, high throughput screening/drug discovery, DNA sequencing/arrays, genomics and proteomics. Typical applications might include studies of macromolecular dynamics and conformation, intracellular chemistry, and gene expression. The journal also publishes papers that describe the synthesis and characterization of new fluorophores, particularly those displaying unique sensitivities and/or optical properties. In addition to original articles, the Journal also publishes reviews, rapid communications, short communications, letters to the editor, topical news articles, and technical and design notes.
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