Epidemiology and Comorbidities of Psychodermatologic Conditions.

IF 3.1 4区 医学 Q2 DERMATOLOGY
Parsa Abdi, Tarek Turk, Zaim Haq, Michael J Diaz, Marlene Dytoc
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引用次数: 0

Abstract

Introduction: Psychodermatologic conditions include primary psychodermatologic disorders (PPDs), psychological conditions manifesting with dermatologic symptoms, and psychophysiological disorders, dermatologic conditions influenced by psychological stress. Despite their clinical significance and considerable impact on quality of life, the comprehensive epidemiology and neuropsychiatric comorbidity profiles of these disorders remain limited.

Objectives: To evaluate the prevalence and comorbidity profiles of psychodermatologic conditions in a diverse, population-based cohort.

Methods: A nested, case-control study was conducted using data from the All of us research program. From 287,011 eligible participants, 984 patients with PPDs (trichotillomania, skin picking disorder, dermatitis artefacta, body dysmorphic disorder, delusions of parasitosis) and 40,535 patients with psychophysiological disorders (psoriasis, atopic dermatitis, acne vulgaris, hidradenitis suppurativa, vulvodynia) were identified using International Classification of Diseases, 10th Revision, Clinical Modification codes. Each patient was paired with 4 controls based on age, sex, and race/ethnicity using nearest-neighbor propensity score matching. Multivariable logistic regression calculated adjusted odds ratios (aOR) and 95% confidence intervals to evaluate associations with various neuropsychiatric comorbidities.

Results: PPDs showed low point prevalences (range: ≤0.01-0.17%) but demonstrated markedly higher odds of neuropsychiatric comorbidities, including depressive disorders (range: aOR, 5.72-13.94), anxiety disorders (range: aOR, 5.96-8.40), and personality disorders (range: aOR, 8.67-13.56 Psychophysiological disorders had higher prevalence rates (range: 0.14%-5.72%) but showed more moderate associations, including depressive disorders (range: aOR, 2.24-3.13), neurodevelopmental disorders (range: aOR, 1.20-2.36), and sleep-wake disorders (range: aOR, 2.25-3.95).

Conclusions: Findings reveal distinct but overlapping comorbidity profiles between PPDs and psychophysiological disorders, emphasizing the need for tailored interventions that address the psychosocial and biological complexities of these conditions.

精神皮肤病的流行病学和合并症。
精神皮肤病包括原发性精神皮肤病(PPDs),以皮肤症状为表现的心理疾病,以及心理生理疾病,受心理应激影响的皮肤疾病。尽管它们的临床意义和对生活质量的相当大的影响,这些疾病的综合流行病学和神经精神合并症概况仍然有限。目的:在一个多样化的、以人群为基础的队列中评估精神皮肤病的患病率和合并症。方法:采用巢式病例对照研究,采用“我们所有人”研究项目的数据。从287,011名符合条件的参与者中,使用国际疾病分类第10版临床修改代码,确定了984例PPDs(拔毛癖、抓皮障碍、人工皮炎、身体畸形障碍、寄生虫病妄想)和40,535例心理生理障碍(牛皮癣、特应性皮炎、寻常性痤疮、化脓性汗腺炎、外阴痛)患者。每个患者根据年龄、性别和种族/民族采用最近邻倾向评分匹配与4个对照配对。多变量逻辑回归计算校正优势比(aOR)和95%置信区间来评估与各种神经精神合并症的关联。结果:PPDs的点患病率较低(范围:≤0.01-0.17%),但神经精神合并症的发生率明显较高,包括抑郁症(范围:aOR, 5.72-13.94)、焦虑症(范围:aOR, 5.96-8.40)和人格障碍(范围:aOR, 8.67-13.56)。心理生理障碍的患病率较高(范围:0.14%-5.72%),但相关性较中度,包括抑郁症(范围:aOR, 2.24-3.13)、神经发育障碍(范围:aOR, 2.24-3.13)。aOR, 1.20-2.36)和睡眠-觉醒障碍(范围:aOR, 2.25-3.95)。结论:研究结果揭示了ppd和心理生理障碍之间不同但重叠的共病特征,强调需要针对这些疾病的社会心理和生物学复杂性进行量身定制的干预。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
3.70
自引率
4.30%
发文量
98
审稿时长
6-12 weeks
期刊介绍: Journal of Cutaneous Medicine and Surgery (JCMS) aims to reflect the state of the art in cutaneous biology and dermatology by providing original scientific writings, as well as a complete critical review of the dermatology literature for clinicians, trainees, and academicians. JCMS endeavours to bring readers cutting edge dermatologic information in two distinct formats. Part of each issue features scholarly research and articles on issues of basic and applied science, insightful case reports, comprehensive continuing medical education, and in depth reviews, all of which provide theoretical framework for practitioners to make sound practical decisions. The evolving field of dermatology is highlighted through these articles. In addition, part of each issue is dedicated to making the most important developments in dermatology easily accessible to the clinician by presenting well-chosen, well-written, and highly organized information in a format that is interesting, clearly presented, and useful to patient care.
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