The association between herpes zoster vaccination and the decreased risk of dementia: A systematic review and meta-analysis of cohort studies.

IF 3.1 3区医学 Q2 NEUROSCIENCES

Journal of Alzheimer's Disease Pub Date : 2025-06-23 DOI:10.1177/13872877251351593

Yishu Yin, Jie Deng, Jue Liu

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引用次数: 0

Abstract

BackgroundHerpes zoster (HZ) infection may increase the risk of dementia, that causes a heavy socioeconomic burden. However, the epidemiological evidence between HZ vaccination and the risk of dementia remains inconclusive.ObjectiveThis meta-analysis was conducted to investigate the effect of HZ vaccination on the onset of dementia.MethodsWe searched PubMed, EMBASE, Web of Science, Science Direct, and Scopus for cohort studies assessing the association between HZ vaccination and dementia risk up to 20th January 2025. Hazard ratios (HRs) with 95% confidence intervals (CIs) were pooled adopting a random-effect model.ResultsFour eligible studies were included in the systematic review and five retrospective cohort studies in the meta-analysis. Among 14,493,383 dementia-free participants at baseline, 427,309 dementia cases occurred during 36-95 months of follow-up. All studies were of high quality. Pooled analysis of adjusted HRs indicated that HZ vaccination could reduce dementia risk by 29% (HR = 0.71, 95% CI: 0.66-0.76, I² = 97.15%). Subgroup analyses revealed heterogeneity linked to definitions of dementia, exposure measurements, vaccination doses, deprivation index, and region. The results were stable in the sensitivity analyses, and no publication bias was found.ConclusionsHZ vaccination was notably related to a reduced risk of dementia. More mechanistic studies and epidemiological studies are warranted.

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带状疱疹疫苗接种与痴呆风险降低之间的关系：队列研究的系统回顾和荟萃分析。

带状疱疹（HZ）感染可能增加痴呆的风险，从而造成沉重的社会经济负担。然而，HZ疫苗接种与痴呆风险之间的流行病学证据仍然没有定论。目的本荟萃分析旨在探讨HZ疫苗接种对痴呆发病的影响。方法：我们检索PubMed、EMBASE、Web of Science、Science Direct和Scopus，以评估2025年1月20日之前HZ疫苗接种与痴呆风险之间关系的队列研究。采用随机效应模型合并95%置信区间的风险比（hr）。结果系统评价纳入4项符合条件的研究，荟萃分析纳入5项回顾性队列研究。在14493383名无痴呆的参与者中，在36-95个月的随访期间发生了427309例痴呆病例。所有的研究都是高质量的。校正HR的合并分析表明，接种HZ疫苗可使痴呆风险降低29% （HR = 0.71, 95% CI: 0.66-0.76, I2 = 97.15%）。亚组分析揭示了痴呆定义、暴露测量、疫苗剂量、剥夺指数和地区的异质性。敏感性分析结果稳定，未发现发表偏倚。结论接种shz疫苗可显著降低痴呆风险。有必要进行更多的机理研究和流行病学研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Alzheimer's Disease 医学-神经科学

CiteScore

6.40

自引率

7.50%

发文量

1327

审稿时长

2 months

期刊介绍： The Journal of Alzheimer''s Disease (JAD) is an international multidisciplinary journal to facilitate progress in understanding the etiology, pathogenesis, epidemiology, genetics, behavior, treatment and psychology of Alzheimer''s disease. The journal publishes research reports, reviews, short communications, hypotheses, ethics reviews, book reviews, and letters-to-the-editor. The journal is dedicated to providing an open forum for original research that will expedite our fundamental understanding of Alzheimer''s disease.