Autoimmune Polyglandular Syndrome Type 2 Presentation with Alopecia Universalis, Hashimoto's Disease, and Addison's Disease.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL
International Medical Case Reports Journal Pub Date : 2025-06-17 eCollection Date: 2025-01-01 DOI:10.2147/IMCRJ.S515059
Karla Denisse Sales-Morales, Nazhira Torres-Neme, Vladimir Barrera-Villanueva, Alejandro Martínez-Carreón
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引用次数: 0

Abstract

Autoimmune polyglandular syndrome type 2 (APS2) is characterized by the coexistence of primary adrenal insufficiency with autoimmune thyroid disease and/or type 1 diabetes. APS2 frequently includes conditions affecting non-endocrine organs, such as alopecia, vitiligo, celiac disease, and autoimmune gastritis associated with vitamin B12 deficiency. We report the case of a 30-year-old male with a history of Hashimoto's disease and alopecia universalis, who presented with diarrhea, anorexia, hypoglycemia, and abdominal pain. Physical examination revealed orthostatic hypotension, a non-tender abdomen, and generalized hair loss. Initial laboratory workup showed hyponatremia and hyperkalemia. Further testing, including serum cortisol, ACTH, aldosterone, and 21-hydroxylase antibodies, confirmed the diagnosis of Addison's disease. The patient was treated with prednisone and fludrocortisone. Only two previous cases of APS2 associated with alopecia universalis have been reported: one with concurrent Crohn's disease and another with hypoparathyroidism. This case highlights the importance of recognizing non-endocrine manifestations in patients with autoimmune endocrinopathies to facilitate earlier diagnosis and management.

自身免疫性多腺综合征2型表现为普遍秃、桥本病和艾迪生病。
自身免疫性多腺综合征2型(APS2)的特点是原发性肾上腺功能不全与自身免疫性甲状腺疾病和/或1型糖尿病共存。APS2通常包括影响非内分泌器官的疾病,如脱发、白癜风、乳糜泻和与维生素B12缺乏相关的自身免疫性胃炎。我们报告一例30岁男性,有桥本氏病和脱发史,表现为腹泻、厌食症、低血糖和腹痛。体格检查发现体位性低血压,腹部无压痛,全身性脱发。最初的实验室检查显示低钠血症和高钾血症。进一步的检测,包括血清皮质醇、ACTH、醛固酮和21-羟化酶抗体,证实了Addison病的诊断。患者给予强的松和氟化可的松治疗。既往仅有2例APS2与普遍性脱发相关的病例被报道:1例并发克罗恩病,另1例并发甲状旁腺功能减退。本病例强调了认识自身免疫性内分泌病变患者的非内分泌表现以促进早期诊断和治疗的重要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
International Medical Case Reports Journal
International Medical Case Reports Journal MEDICINE, GENERAL & INTERNAL-
CiteScore
1.40
自引率
0.00%
发文量
135
审稿时长
16 weeks
期刊介绍: International Medical Case Reports Journal is an international, peer-reviewed, open access, online journal publishing original case reports from all medical specialties. Submissions should not normally exceed 3,000 words or 4 published pages including figures, diagrams and references. As of 1st April 2019, the International Medical Case Reports Journal will no longer consider meta-analyses for publication.
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