Statins could improve short-term prognosis in patients with traumatic brain injury: a propensity-matched cohort study.

IF 4.6 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2025-06-23 DOI:10.1007/s10787-025-01803-0

Ping Li, Qiang Liu, Zhuo Zhang, Hu Nie

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引用次数: 0

Abstract

Objectives: To investigate whether the use of statins could improve the short-term prognosis of traumatic brain injury (TBI) patients and explore the relationship between the initiation time and duration of post-traumatic statins treatment and short-term prognosis.

Methods: TBI patients in the MIMIC IV database were divided into a statin group and a control group. A comparison was made between them in terms of short-term prognosis, including ICU mortality, in-hospital mortality, 28-day mortality, and 90-day mortality. Three subgroup analyses were conducted in this study. Propensity score matching (PSM) method was employed to balance the baseline characteristics. Further stratification based on statin treatment initiation time and duration resulted in four groups.

Results: A total of 1124 eligible TBI patients were included in this study. Before PSM, there were no significant differences between the two groups in terms of the four indexes. After PSM, the statin group showed significantly lower ICU mortality, in-hospital mortality, 28-day mortality, and 90-day mortality compared to the control group. Similarly, after conducting PSM for the three subgroup analyses, similar results were obtained for the GCS < 8 and age greater than 65 years subgroups. In the subgroup analysis of the cohort aged 65 years or under, there were no significant differences in the four metrics between the two groups. The analysis found no discernible correlation between the initiation time and duration of statin treatment and TBI patient prognosis.

Conclusion: Post-traumatic use of statins can improve the short-term prognosis of TBI patients. In comparison to patients aged ≤ 65 years, TBI patients aged > 65 years who use statin drugs experience significantly better short-term prognosis. The correlation between the initiation time and duration of statin treatment and the prognosis of TBI patients warrants further investigation.

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他汀类药物可以改善创伤性脑损伤患者的短期预后：一项倾向匹配的队列研究。

目的：探讨他汀类药物是否能改善创伤性脑损伤（TBI）患者的短期预后，并探讨创伤后他汀类药物治疗的起始时间和持续时间与短期预后的关系。方法：将MIMIC IV数据库中的TBI患者分为他汀类药物组和对照组。比较两组患者的短期预后，包括ICU死亡率、住院死亡率、28天死亡率和90天死亡率。本研究进行了三个亚组分析。采用倾向得分匹配（PSM）方法平衡基线特征。根据他汀类药物治疗开始时间和持续时间进一步分层，结果分为四组。结果：本研究共纳入1124例符合条件的TBI患者。PSM前，两组在四项指标上均无显著差异。PSM后，与对照组相比，他汀类药物组ICU死亡率、住院死亡率、28天死亡率和90天死亡率均显著降低。同样，在对三个亚组分析进行PSM后，GCS也得到了类似的结果。结论：创伤后使用他汀类药物可以改善TBI患者的短期预后。与年龄≤65岁的TBI患者相比，bb0 ~ 65岁的TBI患者使用他汀类药物的短期预后明显更好。他汀类药物治疗的开始时间和持续时间与TBI患者预后的相关性值得进一步研究。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]