Acteoside as a multifunctional natural glycoside: therapeutic potential across various diseases.

IF 4.6 2区医学 Q2 IMMUNOLOGY

Inflammopharmacology Pub Date : 2025-06-23 DOI:10.1007/s10787-025-01811-0

Reham A Mohammed, Ahmed S Kamel, Merhan O Hindam, Ahmed M El-Dessouki, Hend A Hamouda, Nehal M Ramadan, Sarah S Mohamed, Riham A El-Shiekh, Nada M Kamel

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引用次数: 0

Abstract

Phenylethanoid glycosides are naturally occurring water-soluble molecules with remarkable biological characteristics that are abundant throughout the plant world. Acteoside (AC) is a phenylethanoid glycoside that was first discovered in mullein, but is also found in various other plant species. It has four moieties: caffeic acid, glucose, rhamnose, and phenylethyl alcohol. AC is an important bioactive natural compound isolated from many plant species. Extracts from different plant species, including Barleria prionitis, B. lupulina, Rhinacanthus nasutus, Orthosiphon aristatus, and Nicoteba betonica, have high quantities of AC. AC is hydrophilic in nature, and it has several bioactivities such as anti-inflammatory, antibacterial, antiviral, antioxidant, antidiabetic, neuroprotective, cardioprotective, anticancer, and wound-healing properties. In this review, we discuss its prominent pharmacological properties. The findings provide valuable insights for future research on AC which exhibit promising anti-inflammatory activities.

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毛蕊花苷作为一种多功能天然糖苷：治疗多种疾病的潜力。

苯乙醇苷是一种天然存在的水溶性分子，具有显著的生物学特性，在植物界广泛存在。毛蕊花苷（Acteoside， AC）是一种苯乙醇苷，最早在毛蕊花中发现，但也存在于其他多种植物中。它有四个部分：咖啡酸、葡萄糖、鼠李糖和苯乙醇。AC是一种重要的天然活性化合物，从多种植物中分离得到。不同植物的提取物中含有大量的AC，包括朊芽孢杆菌、红斑狼疮芽孢杆菌、鼻棘、直虹吸、白烟等。AC具有亲水性，具有抗炎、抗菌、抗病毒、抗氧化、抗糖尿病、神经保护、心脏保护、抗癌和伤口愈合等生物活性。在这篇综述中，我们讨论了其突出的药理特性。这一发现为今后研究具有良好抗炎活性的AC提供了有价值的见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Inflammopharmacology IMMUNOLOGYTOXICOLOGY-TOXICOLOGY

CiteScore

8.00

自引率

3.40%

发文量

200

期刊介绍： Inflammopharmacology is the official publication of the Gastrointestinal Section of the International Union of Basic and Clinical Pharmacology (IUPHAR) and the Hungarian Experimental and Clinical Pharmacology Society (HECPS). Inflammopharmacology publishes papers on all aspects of inflammation and its pharmacological control emphasizing comparisons of (a) different inflammatory states, and (b) the actions, therapeutic efficacy and safety of drugs employed in the treatment of inflammatory conditions. The comparative aspects of the types of inflammatory conditions include gastrointestinal disease (e.g. ulcerative colitis, Crohn''s disease), parasitic diseases, toxicological manifestations of the effects of drugs and environmental agents, arthritic conditions, and inflammatory effects of injury or aging on skeletal muscle. The journal has seven main interest areas: -Drug-Disease Interactions - Conditional Pharmacology - i.e. where the condition (disease or stress state) influences the therapeutic response and side (adverse) effects from anti-inflammatory drugs. Mechanisms of drug-disease and drug disease interactions and the role of different stress states -Rheumatology - particular emphasis on methods of measurement of clinical response effects of new agents, adverse effects from anti-rheumatic drugs -Gastroenterology - with particular emphasis on animal and human models, mechanisms of mucosal inflammation and ulceration and effects of novel and established anti-ulcer, anti-inflammatory agents, or antiparasitic agents -Neuro-Inflammation and Pain - model systems, pharmacology of new analgesic agents and mechanisms of neuro-inflammation and pain -Novel drugs, natural products and nutraceuticals - and their effects on inflammatory processes, especially where there are indications of novel modes action compared with conventional drugs e.g. NSAIDs -Muscle-immune interactions during inflammation [...]