{"title":"SERCA blockade as a treatment strategy for obesity.","authors":"Suha Al-Naimi, Rizwan Qaisar","doi":"10.1007/s00421-025-05852-9","DOIUrl":null,"url":null,"abstract":"<p><p>Sarco/endoplasmic reticulum calcium ATPase (SERCA) pump is essential for maintaining calcium homeostasis in various cell types, including adipocytes. The SERCA function is closely associated with metabolic health, as the dysregulation of SERCA is implicated in the development of obesity. Thus, regulating SERCA may be clinically relevant for treating obesity and related complications. We discuss various pharmacological and genetic tools to regulate SERCA function for treating obesity. Next, we discuss preclinical and clinical data on the therapeutic efficacy of regulating SERCA in obesity. We also discuss sarcolipin, a SERCA-associated inhibitory protein, as a molecular target for regulating SERCA. Lastly, we discuss challenges, clinical implications, and future directions of regulating SERCA for treating obesity.</p>","PeriodicalId":12005,"journal":{"name":"European Journal of Applied Physiology","volume":" ","pages":"2383-2400"},"PeriodicalIF":2.7000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"European Journal of Applied Physiology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00421-025-05852-9","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/6/23 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"PHYSIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Sarco/endoplasmic reticulum calcium ATPase (SERCA) pump is essential for maintaining calcium homeostasis in various cell types, including adipocytes. The SERCA function is closely associated with metabolic health, as the dysregulation of SERCA is implicated in the development of obesity. Thus, regulating SERCA may be clinically relevant for treating obesity and related complications. We discuss various pharmacological and genetic tools to regulate SERCA function for treating obesity. Next, we discuss preclinical and clinical data on the therapeutic efficacy of regulating SERCA in obesity. We also discuss sarcolipin, a SERCA-associated inhibitory protein, as a molecular target for regulating SERCA. Lastly, we discuss challenges, clinical implications, and future directions of regulating SERCA for treating obesity.
期刊介绍：
The European Journal of Applied Physiology (EJAP) aims to promote mechanistic advances in human integrative and translational physiology. Physiology is viewed broadly, having overlapping context with related disciplines such as biomechanics, biochemistry, endocrinology, ergonomics, immunology, motor control, and nutrition. EJAP welcomes studies dealing with physical exercise, training and performance. Studies addressing physiological mechanisms are preferred over descriptive studies. Papers dealing with animal models or pathophysiological conditions are not excluded from consideration, but must be clearly relevant to human physiology.
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