Certain Metabolic Syndrome Component Combinations are Linked to Increased Risk of Hypogonadism in Taiwanese Men.

IF 3 3区医学 Q3 ENDOCRINOLOGY & METABOLISM

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pub Date : 2025-06-18 eCollection Date: 2025-01-01 DOI:10.2147/DMSO.S483344

Yu-Han Hong, Kuang-Chen Hung, Chih-Li Lin, Chia-Lien Hung, Shih-Kai Tu, Deng-Ho Yang, Chun-Cheng Liao

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引用次数: 0

Abstract

Purpose: This study examined the association between specific combinations of metabolic syndrome (MS) components and the risk of hypogonadism in Taiwanese men.

Patients and methods: We retrospectively analyzed 6,986 men who underwent health screening from 2009 to 2017. MS was defined as meeting at least three of five criteria: waist circumference (W), triglycerides (T), high-density lipoprotein cholesterol (H), fasting glucose (F), and blood pressure (B). Hypogonadism was defined as total testosterone <300 ng/dL. Differences in MS component prevalence between men with and without hypogonadism were compared. Logistic regression adjusted for age and body mass index was used to assess associations.

Results: Among all participants, 6,221 (89.0%) had hypogonadism. The prevalence of MS components was significantly higher in this group (p < 0.001). The risk of hypogonadism increased with the number of MS compon ents. Notably, the combinations F-H-W, F-H-B-W, and F-T-H-B-W were associated with significantly higher odds of hypogonadism.

Conclusion: Specific MS component combinations are strongly associated with increased hypogonadism risk in Taiwanese men. These findings suggest that MS composition, not just its presence, should be considered in evaluating testosterone deficiency.

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台湾男性某些代谢综合征成分组合与性腺功能减退风险增加有关。

目的：本研究探讨台湾男性代谢症候群（MS）成分的特定组合与性腺功能减退风险的关系。患者和方法：我们回顾性分析了2009年至2017年接受健康筛查的6986名男性。MS被定义为至少满足五个标准中的三个：腰围(W)，甘油三酯(T)，高密度脂蛋白胆固醇(H)，空腹血糖(F)和血压(B)。性腺功能减退被定义为总睾酮水平。结果：在所有参与者中，6221（89.0%）患有性腺功能减退。该组MS成分的患病率显著高于对照组（p < 0.001）。性腺功能减退的风险随着MS成分的增加而增加。值得注意的是，F-H-W、F-H-B-W和F-T-H-B-W的组合与性腺功能减退的几率显著增高相关。结论：特定MS成分组合与台湾男性性腺功能减退风险增加密切相关。这些发现表明，在评估睾酮缺乏症时，应考虑质谱组成，而不仅仅是其存在。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy Pharmacology, Toxicology and Pharmaceutics-Pharmacology

CiteScore

5.90

自引率

6.10%

发文量

431

审稿时长

16 weeks

期刊介绍： An international, peer-reviewed, open access, online journal. The journal is committed to the rapid publication of the latest laboratory and clinical findings in the fields of diabetes, metabolic syndrome and obesity research. Original research, review, case reports, hypothesis formation, expert opinion and commentaries are all considered for publication.