Off-Label but On-Target: Sacral Neuromodulation for Neurogenic Bladder Dysfunction.

IF 2.9 2区医学 Q2 UROLOGY & NEPHROLOGY

Current Urology Reports Pub Date : 2025-06-23 DOI:10.1007/s11934-025-01280-6

Keianna Vogel, Nissrine Nakib

{"title":"Off-Label but On-Target: Sacral Neuromodulation for Neurogenic Bladder Dysfunction.","authors":"Keianna Vogel, Nissrine Nakib","doi":"10.1007/s11934-025-01280-6","DOIUrl":null,"url":null,"abstract":"Purpose of review: Neurogenic bladder dysfunction (NBD) is a frequent complication of neurological diseases including Parkinson's disease, multiple sclerosis, spinal cord injury, and spina bifida. Managing NBD remains challenging, especially for patients who fail to respond to standard therapies. Sacral neuromodulation (SNM), though FDA-approved for non-neurogenic conditions, is increasingly explored off-label in neurogenic populations.Recent findings: Recent studies demonstrate that SNM can improve lower urinary tract symptoms, bladder storage, and emptying in select NBD patients. Small case series and retrospective reviews suggest reduced catheterization and medication use. Technological advances, such as closed-loop systems and MRI-compatible devices, are broadening SNM's clinical potential. SNM is emerging as a valuable, minimally invasive treatment for neurogenic bladder dysfunction. Careful patient selection and understanding of underlying pathophysiology are essential for success. As evidence grows and device innovations continue, SNM could reshape management strategies for patients with neurogenic bladder.","PeriodicalId":11112,"journal":{"name":"Current Urology Reports","volume":"26 1","pages":"52"},"PeriodicalIF":2.9000,"publicationDate":"2025-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12185588/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Current Urology Reports","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s11934-025-01280-6","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"UROLOGY & NEPHROLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose of review: Neurogenic bladder dysfunction (NBD) is a frequent complication of neurological diseases including Parkinson's disease, multiple sclerosis, spinal cord injury, and spina bifida. Managing NBD remains challenging, especially for patients who fail to respond to standard therapies. Sacral neuromodulation (SNM), though FDA-approved for non-neurogenic conditions, is increasingly explored off-label in neurogenic populations.

Recent findings: Recent studies demonstrate that SNM can improve lower urinary tract symptoms, bladder storage, and emptying in select NBD patients. Small case series and retrospective reviews suggest reduced catheterization and medication use. Technological advances, such as closed-loop systems and MRI-compatible devices, are broadening SNM's clinical potential. SNM is emerging as a valuable, minimally invasive treatment for neurogenic bladder dysfunction. Careful patient selection and understanding of underlying pathophysiology are essential for success. As evidence grows and device innovations continue, SNM could reshape management strategies for patients with neurogenic bladder.

查看原文本刊更多论文

标签外但符合目标：神经源性膀胱功能障碍的骶神经调节。

综述目的：神经源性膀胱功能障碍（NBD）是帕金森病、多发性硬化症、脊髓损伤和脊柱裂等神经系统疾病的常见并发症。管理NBD仍然具有挑战性，特别是对于那些对标准治疗无效的患者。骶骨神经调节（SNM），虽然fda批准用于非神经源性疾病，但越来越多地在神经源性人群中进行标签外探索。最近的发现：最近的研究表明，SNM可以改善选定的NBD患者的下尿路症状、膀胱储存和排空。小病例系列和回顾性评价建议减少导管插入术和药物使用。技术进步，如闭环系统和核磁共振兼容设备，正在扩大SNM的临床潜力。SNM是一种有价值的微创治疗神经源性膀胱功能障碍的方法。仔细的病人选择和理解潜在的病理生理是成功的必要条件。随着证据的增长和设备的不断创新，SNM可以重塑神经源性膀胱患者的治疗策略。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Current Urology Reports UROLOGY & NEPHROLOGY-

CiteScore

4.60

自引率

3.80%

发文量

期刊介绍： This journal intends to review the most important, recently published findings in the field of urology. By providing clear, insightful, balanced contributions by international experts, the journal elucidates current and emerging approaches to the care and prevention of urologic diseases and conditions. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas, such as benign prostatic hyperplasia, erectile dysfunction, female urology, and kidney disease. Section Editors, in turn, select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An international Editorial Board reviews the annual table of contents, suggests articles of special interest to their country/region, and ensures that topics are current and include emerging research. Commentaries from well-known figures in the field are also provided.