Subepithelial Lesions of the Ocular Surface: A Review.

IF 0.8 Q4 OPHTHALMOLOGY

Current Ophthalmology Reports Pub Date : 2025-01-01 Epub Date: 2025-06-21 DOI:10.1007/s40135-025-00335-8

Wisam Najdawi, Wendy J Li, Sofia De Arrigunaga, Mona M Amer, Anat Galor, Carol L Karp

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Abstract

Purpose of review: Subepithelial lesions of the ocular surface represent a diverse group of pathologies which may be difficult to diagnose clinically. Some of these lesions are relatively uncommon, may result in systemic manifestations, or occur secondary to systemic disease. The purpose of this review is to summarize current approaches to the diagnosis and management of six subepithelial conjunctival lesions.

Recent findings: The standard for the diagnosis of subconjunctival lesions remains histopathologic evaluation; however, high-resolution anterior segment optical coherence tomography (HR-OCT) is a useful supplemental diagnostic tool that may facilitate diagnosis. Recent advancements in the management of subconjunctival lesions include targeted systemic therapies in conjunctival melanoma and ultra-low dose radiation radiotherapy in conjunctival lymphoma.

Summary: The development of HR-OCT has provided clinicians with valuable supplemental diagnostic information to guide the diagnosis of subepithelial lesions. Additionally, novel treatment modalities may provide an alternative to traditional surgical interventions in some pathologies.

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眼表上皮下病变：综述。

回顾的目的：眼表上皮下病变是一组不同的病理，可能难以临床诊断。其中一些病变相对不常见，可能导致全身性表现，或继发于全身性疾病。本综述的目的是总结目前的方法诊断和处理六上皮下结膜病变。最近发现：结膜下病变的诊断标准仍然是组织病理学评估；然而，高分辨率前段光学相干断层扫描（HR-OCT）是一种有用的辅助诊断工具，可能有助于诊断。结膜下病变治疗的最新进展包括结膜黑色素瘤的靶向全身治疗和结膜淋巴瘤的超低剂量放射治疗。摘要：HR-OCT的发展为临床医生提供了有价值的补充诊断信息来指导上皮下病变的诊断。此外，新的治疗方式可能为某些病理提供传统手术干预的替代方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Current Ophthalmology Reports Medicine-Ophthalmology

CiteScore

2.00

自引率

0.00%

发文量

期刊介绍： This journal aims to offer expert review articles on the most significant recent developments in the field of ophthalmology. By providing clear, insightful, balanced contributions, the journal intends to serve those who diagnose, treat, manage, and prevent ocular conditions and diseases. We accomplish this aim by appointing international authorities to serve as Section Editors in key subject areas across the field. Section Editors select topics for which leading experts contribute comprehensive review articles that emphasize new developments and recently published papers of major importance, highlighted by annotated reference lists. An Editorial Board of more than 20 internationally diverse members reviews the annual table of contents, ensures that topics include emerging research, and suggests topics of special importance to their country/region. Topics covered may include age-related macular degeneration; diabetic retinopathy; dry eye syndrome; glaucoma; pediatric ophthalmology; ocular infections; refractive surgery; and stem cell therapy.