Investigating Utility of the Preoperative Systemic Immune-Inflammatory Index in Chronic Rhinosinusitis

IF 1.5 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2025-06-23 DOI:10.1111/coa.70001

Abdullah A. Memon, David M. Poetker, Jazzmyne Adams, David R. Friedland, Lauren M. North

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Abstract

Background

CRS is a multifactorial pathology associated with inflammatory comorbidities including asthma, allergic rhinitis (AR) and nasal polyposis (NP). The systemic immune-inflammatory index (SII) has been shown to have prognostic efficacy in gauging systemic inflammation.

Objective

To evaluate the potential utility of the SII in assessing the extent of surgery and CRS-mediated comorbidities in patients undergoing ESS.

Methods

13-year retrospective study of 147 adults undergoing ESS with preoperative platelet, neutrophil and lymphocyte counts for SII calculation ((platelets × neutrophils)/lymphocytes). Lund-Mackay scores, surgery extent and comorbidities were collected. For analyses, numeric versus categorical utilised a two-tailed t-test, categorical versus categorical utilised a Chi-square test of independence. Significance set at p < 0.05.

Results

147 patients met criteria, 75 had CRS and 72 had other sinonasal conditions (exploratory control). Average SII for all patients was 1080.6 ± 1134.6 (range 0–8119, median 735). Significant differences in average SII existed between CRS and other sinonasal disorders (1479 ± 1186 vs. 1007 ± 1082, p = 0.013). No significant differences were found in Lund-McKay scores between CRS patients with SII above or below previously reported critical thresholds (i.e., SII > 330 or > 895.6). Significant inverse association was observed between comorbidities and SII in CRS patients; those with SII < 895.6 had statistically significant higher prevalence of asthma (p = 0.001) and AR (p = 0.0143). No association was found between SII and nasal polyps, or with number of sinuses opened during surgery.

Conclusion

CRS patients requiring ESS had higher SII values than those with other indications. Contrary to previous reports, our study found that SII in CRS patients was inversely associated with asthma and AR, and was not associated with surgical extent.

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探讨术前全身免疫炎症指数在慢性鼻窦炎中的应用。

背景：CRS是一种多因素病理，与哮喘、变应性鼻炎（AR）和鼻息肉病（NP）等炎性合并症相关。全身性免疫炎症指数（SII）已被证明在衡量全身性炎症方面具有预后功效。目的：评估SII在评估ESS患者手术程度和crs介导的合并症方面的潜在效用。方法：对147例接受ESS手术的成人患者进行13年回顾性研究，术前进行血小板、中性粒细胞和淋巴细胞计数（（血小板×中性粒细胞）/淋巴细胞）SII计算。收集隆德-麦凯评分、手术范围和合并症。对于分析，数值与分类使用双尾t检验，分类与分类使用卡方独立性检验。结果：147例患者符合标准，75例有CRS， 72例有其他鼻窦疾病（探索性对照）。所有患者的平均SII为1080.6±1134.6（范围0-8119，中位数735）。CRS与其他鼻窦疾病的平均SII差异有统计学意义（1479±1186比1007±1082，p = 0.013）。伴有SII的CRS患者的lnd - mckay评分高于或低于先前报道的临界阈值（即SII bbbb330或bbbb895.6），未发现显著差异。CRS患者合并症与SII呈显著负相关；结论：CRS患者需要ESS的SII值高于其他适应症患者。与以往报道相反，我们的研究发现CRS患者SII与哮喘和AR呈负相关，与手术范围无关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.