Effect of Cannabidiol and Δ9-tetrahydrocannabinol on Anti-Inflammatory Lipid Mediator Synthesis in Humans.

IF 3.1 4区 医学 Q2 PHARMACOLOGY & PHARMACY
Alan W J Morris, Raeghan L Mueller, Cristina Sempio, Jost Klawitter, Angela D Bryan, L Cinnamon Bidwell, Kent E Hutchison
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引用次数: 0

Abstract

Background: Eicosanoids-lipid mediators derived from polyunsaturated fatty acids such as arachidonic acid-have a notable role in inflammatory signaling. Cannabidiol (CBD) and Δ9-tetrahydrocannabinol (THC) have been shown in preclinical studies to modulate inflammatory pathways the modulating the enzymes that generate eicosanoids, namely lipoxygenase (LOX), cyclooxygenase (COX), and cytochrome P450 (CYP450). Methods: This present study aimed to investigate how CBD and THC effect plasma levels of eicosanoids generated through LOX, COX, and cytochrome P450 (CYP450) pathways. Using plasma sample data from multiple clinical studies, we tested the hypothesis that high-CBD cannabis use would increase eicosanoid levels compared with high-THC cannabis. Results: Following cannabis use, high-CBD cannabis led to a rise in plasma eicosanoids, particularly lipoxins, while high-THC cannabis did not. Conclusions: CBD promoted anti-inflammatory eicosanoid production via the 15-LOX pathway, therefore supporting the potential role of CBD as a therapeutic candidate for inflammatory diseases.

大麻二酚和Δ9-tetrahydrocannabinol对人体抗炎脂质介质合成的影响。
背景:类二十烷酸是源自花生四烯酸等多不饱和脂肪酸的脂质介质,在炎症信号传导中起着重要作用。大麻二酚(CBD)和Δ9-tetrahydrocannabinol (THC)已在临床前研究中显示,通过调节产生类二十烷的酶,即脂氧合酶(LOX)、环氧合酶(COX)和细胞色素P450 (CYP450),来调节炎症途径。方法:本研究旨在探讨CBD和四氢大麻酚如何影响血浆中通过LOX、COX和细胞色素P450 (CYP450)途径产生的类二十烷酸的水平。使用来自多个临床研究的血浆样本数据,我们验证了高cbd大麻使用与高thc大麻相比会增加二十烷酸水平的假设。结果:使用大麻后,高cbd大麻导致血浆类二十烷酸增加,特别是脂毒素,而高thc大麻没有。结论:CBD通过15-LOX途径促进抗炎类二十烷酸的产生,因此支持CBD作为炎症性疾病治疗候选药物的潜在作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Cannabis and Cannabinoid Research
Cannabis and Cannabinoid Research PHARMACOLOGY & PHARMACY-
CiteScore
6.80
自引率
7.90%
发文量
164
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