Unveiling mysteries of aging: the potential of melatonin in preventing neurodegenerative diseases in older adults.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Omer Unal, Nilufer Akgun-Unal, Abdulkerim Kasim Baltaci
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引用次数: 0

Abstract

Neurodegenerative conditions, including Alzheimer's disease, Parkinson's disease, and Huntington's disease, result in a substantial health problem for the elderly, marked by ongoing neuronal degeneration and a deterioration in mental faculties. These disorders are frequently linked to oxidative stress, problems with mitochondria, and persistent inflammation in the brain, which worsen neuronal damage. The neurohormone melatonin, primarily secreted by the pineal gland, has gained recognition as a promising therapeutic agent due to its antioxidant, anti-inflammatory, and neuroprotective effects. Melatonin's functions extend beyond its regulation of circadian rhythms, as research has demonstrated its ability to remove free radicals, improve mitochondrial performance, and adjust immune system responses, ultimately reducing the progression of neurodegenerative disease. Research findings from preclinical and clinical trials imply that taking melatonin supplements could lead to improved cognitive abilities, slower disease progression, and an overall better quality of life for elderly individuals suffering from neurodegenerative conditions. The mechanisms through which melatonin acts, the best dosage, and its long-term effectiveness are still being researched. This review underscores the potential benefits of melatonin as a supplementary treatment for neurodegenerative disorders in older adults, stressing the necessity for additional studies to confirm its efficacy and standardize its use in treatment plans.

揭开衰老之谜:褪黑素在预防老年人神经退行性疾病中的潜力。
神经退行性疾病,包括阿尔茨海默病、帕金森氏病和亨廷顿氏病,会给老年人带来严重的健康问题,其特征是持续的神经元退化和智力退化。这些疾病通常与氧化应激、线粒体问题和大脑持续炎症有关,后者会加重神经元损伤。神经激素褪黑素主要由松果体分泌,由于其抗氧化、抗炎和神经保护作用而被认为是一种有前途的治疗药物。褪黑素的功能不仅仅是调节昼夜节律,研究已经证明它能够清除自由基,改善线粒体性能,调节免疫系统反应,最终减少神经退行性疾病的进展。临床前和临床试验的研究结果表明,服用褪黑素补充剂可以改善认知能力,减缓疾病进展,并改善患有神经退行性疾病的老年人的总体生活质量。褪黑素的作用机制、最佳剂量及其长期有效性仍在研究中。这篇综述强调了褪黑激素作为老年人神经退行性疾病的辅助治疗的潜在益处,强调了进一步研究以确认其疗效并规范其在治疗计划中的使用的必要性。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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