Calorie restriction mimetics against aging and inflammation.

IF 4.4 4区 医学 Q1 GERIATRICS & GERONTOLOGY
Sakshi Chaudhary, Mani Raj Chaudhary, Manoj Kumar Jena, Prasana Kumar Rath, Bidyut Prava Mishra, Biswaranjan Paital, Ashish Vyas, Dipak Kumar Sahoo, Prabhakar Singh, Mohammad Murtaza Mehdi
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Abstract

Geroprotectors, a class of compounds that ameliorate molecular, cellular, or physiological aging-related alterations, have garnered significant attention in the quest to promote healthy aging and extend the human health span. Among these, Calorie Restriction Mimetics (CRMs) have emerged as promising candidates due to their potential to mimic the benefits of calorie restriction, a dietary approach involving reduced calorie intake without malnutrition. Prospective CRMs may include biguanides (metformin and aminoguanidine), which exert effects on the insulin signaling pathway; rapamycin, which interacts with mTOR signaling pathways; and stilbenes (resveratrol), which influences stress signaling pathways and promotes the activation of AMPK, impacting mitochondrial metabolism in addition to the activity of FOXO and sirtuin. Other compounds, such as glycolytic inhibitors, carbohydrate and lipid absorption blockers, polyamines, and polyphenols, which collectively modulate pathways regulating the effects of free radicals, are also under consideration. To propose prospective geroprotective strategies, this article focuses on analyzing the functions of potential CRMs and their mechanisms demonstrating health benefits, the same as that of CR (Calorie Restriction), but without undesirable side effects.

卡路里限制可以对抗衰老和炎症。
Geroprotectors是一类改善分子、细胞或生理衰老相关变化的化合物,在促进健康衰老和延长人类健康寿命方面受到了极大的关注。其中,卡路里限制模仿物(CRMs)已成为有希望的候选人,因为它们有可能模仿卡路里限制的好处,这是一种减少卡路里摄入而不营养不良的饮食方法。前瞻性crm可能包括双胍类药物(二甲双胍和氨基胍),它们对胰岛素信号通路有影响;雷帕霉素,与mTOR信号通路相互作用;二苯乙烯(白藜芦醇),影响应激信号通路,促进AMPK的激活,影响线粒体代谢以及FOXO和sirtuin的活性。其他化合物,如糖酵解抑制剂、碳水化合物和脂质吸收阻滞剂、多胺和多酚,它们共同调节调节自由基作用的途径,也在考虑之中。为了提出前瞻性的老年保护策略,本文重点分析了潜在的CRMs的功能及其显示健康益处的机制,与CR(卡路里限制)相同,但没有不良副作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Biogerontology
Biogerontology 医学-老年医学
CiteScore
8.00
自引率
4.40%
发文量
54
审稿时长
>12 weeks
期刊介绍: The journal Biogerontology offers a platform for research which aims primarily at achieving healthy old age accompanied by improved longevity. The focus is on efforts to understand, prevent, cure or minimize age-related impairments. Biogerontology provides a peer-reviewed forum for publishing original research data, new ideas and discussions on modulating the aging process by physical, chemical and biological means, including transgenic and knockout organisms; cell culture systems to develop new approaches and health care products for maintaining or recovering the lost biochemical functions; immunology, autoimmunity and infection in aging; vertebrates, invertebrates, micro-organisms and plants for experimental studies on genetic determinants of aging and longevity; biodemography and theoretical models linking aging and survival kinetics.
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