PKC in the perspective of dopamine receptor signaling.

Abstract

Protein kinase C (PKC) is widely distributed in various tissues, organs, and cells. By catalyzing the phosphorylation of Ser/Thr residues on various proteins, PKC regulates the metabolism, growth, proliferation, and differentiation of multiple cells and plays a crucial role in transmembrane signal transmission. In dopamine receptor signal transduction, PKC regulates numerous physiological functions, such as dopamine release, internalization of the dopamine transporter, downregulation of dopamine receptors, etc. In disease conditions, hyperactivation of PKC can lead to disorders such as schizophrenia and Parkinson's disease, while reduced PKC signaling may be associated with Alzheimer's disease. In the past few decades, researchers have paid increasing attention to the transduction role of PKC in dopamine receptor signaling, aiming to identify and discover potential targets for dopaminergic diseases. This review, from the perspective of signal transduction between dopamine receptors and PKC, reveals the pivotal hub position of PKC in the intracellular signal transduction network and its regulation of various physiological functions, providing ideas for future research on PKC and therapeutic interventions for dopaminergic diseases.