Sustained-Release Photothermal Microneedles for Postoperative Incisional Analgesia and Wound Healing via Hydrogen Therapy.

IF 14.1 1区 材料科学 Q1 CHEMISTRY, MULTIDISCIPLINARY
Aining Zhang, Xue Jiang, Bingrui Xiong, Jiayi Chen, Xin Liu, Siyuan Wang, Bofu Li, Mian Peng, Wei Li
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Abstract

Effective management of postoperative pain and wound healing presents significant challenges in clinical settings, driving the need for innovative therapeutic approaches. The analgesic and wound healing effects of hydrogen (H2) have gradually been recognized; however, the lack of efficient hydrogen delivery systems remains a major limitation. This study introduces a novel transdermal drug delivery system, which utilizes sustained-release photothermal microneedles (MNs) to ameliorate incisional pain and accelerate wound healing. Polydopamine (PDA)-modified ZIF-8@ammonia borane (AB) nanoparticles with photothermal conversion properties are designed, along with temperature-responsive QX-314-loaded polycaprolactone (PCL) microspheres for controlled release, which are delivered in vivo by dissolvable MNs. In vitro results showed that PDA@ZIF-8@AB nanoparticles can release H2 continuously for up to 5 days in an acidic microenvironment, while the photothermal properties of PDA facilitated controlled release of QX-314 through 6 cycles of near-infrared (NIR) exposure. In vivo experiments demonstrated that the MN system provided sustained analgesia for up to 5 days and promoted wound healing in the acidic microenvironment of postoperative incisions. Upon NIR exposure, the photothermal conversion of PDA activated membrane ion channels and induced thermally triggered deformation of PCL@QX-314 microspheres, allowing for on-demand release of QX-314 and targeted neuronal uptake, thus offering personalized analgesia. In vitro cell experiments and in vivo studies confirmed the biocompatibility of the system. This innovative approach not only highlights the dual role of H2 in pain relief and wound healing but also provides a new personalized treatment strategy for postoperative pain management with promising clinical applications.

缓释光热微针用于氢疗术后切口镇痛和伤口愈合。
术后疼痛和伤口愈合的有效管理在临床环境中提出了重大挑战,推动了对创新治疗方法的需求。氢(H2)的镇痛和伤口愈合作用已逐渐被认识;然而,缺乏有效的氢气输送系统仍然是一个主要的限制。本研究介绍了一种新型的经皮给药系统,该系统利用缓释光热微针(MNs)来改善切口疼痛并加速伤口愈合。设计了具有光热转化特性的聚多巴胺(PDA)修饰ZIF-8@ammonia硼烷(AB)纳米颗粒,以及负载qx -314的温度响应型聚己内酯(PCL)微球,通过可溶的纳米颗粒在体内释放。体外实验结果表明,PDA@ZIF-8@AB纳米颗粒在酸性微环境下可连续释放H2长达5天,而PDA的光热特性有助于QX-314通过6个近红外(NIR)周期的控释。体内实验表明,MN系统在术后切口酸性微环境中提供长达5天的持续镇痛,并促进伤口愈合。在近红外照射下,PDA的光热转换激活膜离子通道,诱导PCL@QX-314微球的热触发变形,允许QX-314按需释放和靶向神经元摄取,从而提供个性化镇痛。体外细胞实验和体内研究证实了该系统的生物相容性。这种创新的方法不仅突出了H2在疼痛缓解和伤口愈合中的双重作用,而且为术后疼痛管理提供了一种新的个性化治疗策略,具有良好的临床应用前景。
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来源期刊
Advanced Science
Advanced Science CHEMISTRY, MULTIDISCIPLINARYNANOSCIENCE &-NANOSCIENCE & NANOTECHNOLOGY
CiteScore
18.90
自引率
2.60%
发文量
1602
审稿时长
1.9 months
期刊介绍: Advanced Science is a prestigious open access journal that focuses on interdisciplinary research in materials science, physics, chemistry, medical and life sciences, and engineering. The journal aims to promote cutting-edge research by employing a rigorous and impartial review process. It is committed to presenting research articles with the highest quality production standards, ensuring maximum accessibility of top scientific findings. With its vibrant and innovative publication platform, Advanced Science seeks to revolutionize the dissemination and organization of scientific knowledge.
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