Bionic Microneedle Patch Inspired by Drosophila Tarsal Paws Boosts Healing in Bacterial Infectious Stomatitis.

Abstract

Bacterial infectious stomatitis (BIS), characterized by severe infections overlaying ulcers, poses complex therapeutic challenges and often results in prolonged healing, leading to significant patient discomfort. To address this clinical challenge, a biomimetic microneedle (MN) suction cup is designed inspired by the tarsal claw of Drosophila. The suction cup component is crafted from polyvinyl alcohol (PVA) hydrogel, while the MN section, embedded within the suction cup, comprises a thermoresponsive and antibacterial composite hydrogel infused with the drug S-nitrosoglutathione (GSNO). This innovative design not only ensures strong adhesion to moist surfaces but also provides substantial antibacterial and anti-inflammatory effects, controlled drug release, active promotion of concentric wound contraction, and enhanced vasodilation, thereby facilitating rapid and comprehensive healing of BIS. The multifunctionality of the MN suction cup patch developed in this study represents a significant innovation over traditional treatment methods and holds potential for widespread application in dental clinics.