Synergistic Nitric Oxide Therapy and Phototherapy Using a Novel Bacteria Scavenger for Treatment of Acute Rhinosinusitis

IF 5.5 2区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biomacromolecules Pub Date : 2025-07-14 DOI:10.1021/acs.biomac.5c00938

Maolin Li , Hui Yan , Tong Li , Yin Liu , Haiping Zhang , Dandan Han , Songgu Wu , Junbo Gong

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Abstract

Acute rhinosinusitis is one of the most prevalent diseases seriously affecting the well-being and quality of life. To address this condition, a novel intelligent liposome nanoparticle (BHL@IR780@LNP) was constructed by coloading the photosensitizer IR780 and a nitric oxide donor (l-arginine-loaded biguanide chitosan–hyaluronic acid composite nanoparticles, BHL) onto liposome nanoparticles composed of cholesterol and soybean phospholipids. Under irradiation with an 808 nm near-infrared laser, BHL@IR780@LNP was able to generate heat and reactive oxygen species, resulting in the precise release of nitric oxide, which effectively killed 97.5% of Escherichia coli and 99.2% of Staphylococcus aureus, respectively. Furthermore, in vivo findings demonstrated that BHL@IR780@LNP+L could effectively eliminate 99.5% of S. aureus at the nasal mucous membrane and significantly reduce inflammatory markers. Overall, this study demonstrates a highly effective antibacterial nanoformulation (BHL@IR780@LNP+L) that innovatively integrates the synergistic effects of heat, reactive oxygen species, and nitric oxide to combat acute rhinosinusitis.

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查看原文本刊更多论文

一种新型细菌清除剂协同一氧化氮治疗和光疗治疗急性鼻窦炎。

急性鼻窦炎是严重影响人类健康和生活质量的常见疾病之一。为了解决这一问题，我们将光敏剂IR780和一氧化氮供体（l-精氨酸负载的双胍壳聚糖-透明质酸复合纳米颗粒BHL）涂覆在由胆固醇和大豆磷脂组成的纳米脂质体上，构建了一种新型智能脂质体纳米颗粒（BHL@IR780@LNP）。在808 nm近红外激光照射下，BHL@IR780@LNP能够产生热量和活性氧，导致一氧化氮的精确释放，分别有效杀死97.5%的大肠杆菌和99.2%的金黄色葡萄球菌。此外，体内实验结果表明BHL@IR780@LNP+L可有效清除99.5%的鼻粘膜金黄色葡萄球菌，并显著降低炎症标志物。总的来说，这项研究展示了一种高效的抗菌纳米制剂（BHL@IR780@LNP+L），它创新地整合了热、活性氧和一氧化氮的协同作用，以对抗急性鼻窦炎。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Biomacromolecules 化学-高分子科学

CiteScore

10.60

自引率

4.80%

发文量

417

审稿时长

1.6 months

期刊介绍： Biomacromolecules is a leading forum for the dissemination of cutting-edge research at the interface of polymer science and biology. Submissions to Biomacromolecules should contain strong elements of innovation in terms of macromolecular design, synthesis and characterization, or in the application of polymer materials to biology and medicine. Topics covered by Biomacromolecules include, but are not exclusively limited to: sustainable polymers, polymers based on natural and renewable resources, degradable polymers, polymer conjugates, polymeric drugs, polymers in biocatalysis, biomacromolecular assembly, biomimetic polymers, polymer-biomineral hybrids, biomimetic-polymer processing, polymer recycling, bioactive polymer surfaces, original polymer design for biomedical applications such as immunotherapy, drug delivery, gene delivery, antimicrobial applications, diagnostic imaging and biosensing, polymers in tissue engineering and regenerative medicine, polymeric scaffolds and hydrogels for cell culture and delivery.