Ya Chen, Xia Zhang, Chengyu Pan, Zhongxiang Xu, Zucai Xu
{"title":"Enlarged Perivascular Space Burden Predicts the Risk of Relapse in Myelin Oligodendrocyte Glycoprotein Antibody-Associated Disease Patients","authors":"Ya Chen, Xia Zhang, Chengyu Pan, Zhongxiang Xu, Zucai Xu","doi":"10.1155/ane/8858684","DOIUrl":null,"url":null,"abstract":"<p><b>Background and Objectives:</b> Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated inflammatory demyelinating disease of the central nervous system, with a complex relapse mechanism involving various factors. The connection between enlarged perivascular spaces (EPVSs) and MOGAD is currently unclear. This study is aimed at exploring the risk factors associated with an increased number of EPVS in MOGAD patients and the association with relapse.</p><p><b>Methods:</b> A retrospective study was conducted on 23 patients with MOGAD. We analyzed the correlation between the number of EPVS and age, disease duration, cerebrospinal fluid (CSF) leukocytes, CSF protein, EDSS scores, albumin quotient, and MOG-IgG titer. We employed linear regression to assess the independent risk factors for the number of EPVS, and Cox regression was used to elucidate the independent factors associated with relapse.</p><p><b>Results:</b> The median total EPVS counts were 8 (IQR 4–9) at the initial brain MRI in patients with MOGAD. The number of total EPVS in patients with MOGAD was significantly positively correlated with CSF protein (<i>ρ</i> = 0.42, <i>p</i> = 0.044), EDSS (<i>r</i> = 0.74, <i>p</i> < 0.0001), QAlb (<i>ρ</i> = 0.48, <i>p</i> = 0.022), serum MOG-IgG titer (<i>ρ</i> = 0.48, <i>p</i> = 0.019), and CSF MOG-IgG titer (<i>ρ</i> = 0.46, <i>p</i> = 0.029). Univariate linear regression analysis indicated that CSF protein (<i>β</i> = 0.45, <i>p</i> = 0.03), EDSS scores (<i>β</i> = 0.6, <i>p</i> = 0.002), serum MOG-IgG titer (<i>β</i> = 0.51, <i>p</i> = 0.014), and CSF anti-MOG-IgG titer (<i>β</i> = 0.64, <i>p</i> = 0.001) were independent factors associated with EPVS counts. EDSS scores (<i>β</i> = 0.49, <i>p</i> = 0.002) and CSF MOG-IgG titer (<i>β</i> = 0.54, <i>p</i> = 0.001) were independent predictors associated with EPVS count in the multivariable linear regression model. Multivariable Cox regression analysis showed that the total number of EPVS was the only variable that revealed a significant effect on relapse (HR = 1.22, 95% CI 1.01–1.47, <i>p</i> = 0.04).</p><p><b>Conclusion:</b> In our cohort, we preliminary explored independent risk factors for increased EPVS. Moreover, EPVS might independently predict the risk of relapse in patients with MOGAD.</p>","PeriodicalId":6939,"journal":{"name":"Acta Neurologica Scandinavica","volume":"2025 1","pages":""},"PeriodicalIF":2.7000,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1155/ane/8858684","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Neurologica Scandinavica","FirstCategoryId":"3","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1155/ane/8858684","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CLINICAL NEUROLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Background and Objectives: Myelin oligodendrocyte glycoprotein antibody-associated disease (MOGAD) is an immune-mediated inflammatory demyelinating disease of the central nervous system, with a complex relapse mechanism involving various factors. The connection between enlarged perivascular spaces (EPVSs) and MOGAD is currently unclear. This study is aimed at exploring the risk factors associated with an increased number of EPVS in MOGAD patients and the association with relapse.
Methods: A retrospective study was conducted on 23 patients with MOGAD. We analyzed the correlation between the number of EPVS and age, disease duration, cerebrospinal fluid (CSF) leukocytes, CSF protein, EDSS scores, albumin quotient, and MOG-IgG titer. We employed linear regression to assess the independent risk factors for the number of EPVS, and Cox regression was used to elucidate the independent factors associated with relapse.
Results: The median total EPVS counts were 8 (IQR 4–9) at the initial brain MRI in patients with MOGAD. The number of total EPVS in patients with MOGAD was significantly positively correlated with CSF protein (ρ = 0.42, p = 0.044), EDSS (r = 0.74, p < 0.0001), QAlb (ρ = 0.48, p = 0.022), serum MOG-IgG titer (ρ = 0.48, p = 0.019), and CSF MOG-IgG titer (ρ = 0.46, p = 0.029). Univariate linear regression analysis indicated that CSF protein (β = 0.45, p = 0.03), EDSS scores (β = 0.6, p = 0.002), serum MOG-IgG titer (β = 0.51, p = 0.014), and CSF anti-MOG-IgG titer (β = 0.64, p = 0.001) were independent factors associated with EPVS counts. EDSS scores (β = 0.49, p = 0.002) and CSF MOG-IgG titer (β = 0.54, p = 0.001) were independent predictors associated with EPVS count in the multivariable linear regression model. Multivariable Cox regression analysis showed that the total number of EPVS was the only variable that revealed a significant effect on relapse (HR = 1.22, 95% CI 1.01–1.47, p = 0.04).
Conclusion: In our cohort, we preliminary explored independent risk factors for increased EPVS. Moreover, EPVS might independently predict the risk of relapse in patients with MOGAD.
期刊介绍:
Acta Neurologica Scandinavica aims to publish manuscripts of a high scientific quality representing original clinical, diagnostic or experimental work in neuroscience. The journal''s scope is to act as an international forum for the dissemination of information advancing the science or practice of this subject area. Papers in English will be welcomed, especially those which bring new knowledge and observations from the application of therapies or techniques in the combating of a broad spectrum of neurological disease and neurodegenerative disorders. Relevant articles on the basic neurosciences will be published where they extend present understanding of such disorders. Priority will be given to review of topical subjects. Papers requiring rapid publication because of their significance and timeliness will be included as ''Clinical commentaries'' not exceeding two printed pages, as will ''Clinical commentaries'' of sufficient general interest. Debate within the speciality is encouraged in the form of ''Letters to the editor''. All submitted manuscripts falling within the overall scope of the journal will be assessed by suitably qualified referees.