Effects and mechanisms of aflatoxin B1 on oocytes and embryo development

IF 6.1 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Ecotoxicology and Environmental Safety Pub Date : 2025-06-24 DOI:10.1016/j.ecoenv.2025.118572

Lang Li , Yangyong Dong , Jiafu Zhao , Yuemin Li , Zhenzhen Wang , Bin Liu , Jingyi Chen , Tongyao Wang , Huihui Gao , Xiong Xiao , Yongju Zhao , Xiaoyan Qiu

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引用次数: 0

Abstract

Aflatoxin B1 (AFB1), a ubiquitous environmental contaminant, poses substantial threats to animal reproductive health. This review thoroughly described the damage effects and summarized the potential mechanisms of AFB1 on reproductive health. Following metabolic activation by cytochrome P450 to form aflatoxin B1–8, 9-epoxide (AFBO), AFB1 disrupts cellular architecture and impairs mitochondrial function. This impairment manifests as suppressed mitochondrial biogenesis, diminished membrane potential, and induction of mitochondrial DNA mutations. Consequently, energy metabolism dysregulation and arrested development occur in oocytes, embryonic cells, granulosa cells, and ovarian somatic cells. AFB1-induced oxidative stress activates apoptotic pathways and perturbs epigenetic reprogramming, thereby disrupting oocyte meiotic progression and gene expression. Furthermore, AFB1 inhibits GPX4 expression, upregulates TFRC and ACSL4 expression, and promotes iron accumulation, collectively driving lipid peroxidation and triggering ferroptosis. This cascade ultimately impedes oocyte maturation and compromises embryonic developmental competence. This study provides novel insights into the reproductive toxicity of AFB1 and establishes a scientific foundation for developing effective preventative and therapeutic strategies.

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黄曲霉毒素B1对卵母细胞和胚胎发育的影响及其机制

黄曲霉毒素B1 （AFB1）是一种普遍存在的环境污染物，对动物生殖健康构成重大威胁。本文综述了AFB1对生殖健康的损害作用，并对其潜在机制进行了综述。在细胞色素P450代谢激活形成黄曲霉毒素b1 - 8,9 -环氧化物（AFBO）后，AFB1破坏细胞结构并损害线粒体功能。这种损伤表现为抑制线粒体生物发生，降低膜电位，并诱导线粒体DNA突变。因此，能量代谢失调和发育受阻发生在卵母细胞、胚胎细胞、颗粒细胞和卵巢体细胞中。afb1诱导的氧化应激激活凋亡通路，扰乱表观遗传重编程，从而破坏卵母细胞减数分裂进程和基因表达。此外，AFB1抑制GPX4表达，上调TFRC和ACSL4表达，促进铁积累，共同驱动脂质过氧化，引发铁下垂。这种级联最终阻碍卵母细胞成熟，损害胚胎发育能力。本研究为AFB1的生殖毒性提供了新的认识，并为制定有效的预防和治疗策略奠定了科学基础。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Ecotoxicology and Environmental Safety 环境科学-毒理学

CiteScore

12.10

自引率

5.90%

发文量

1234

审稿时长

88 days

期刊介绍： Ecotoxicology and Environmental Safety is a multi-disciplinary journal that focuses on understanding the exposure and effects of environmental contamination on organisms including human health. The scope of the journal covers three main themes. The topics within these themes, indicated below, include (but are not limited to) the following: Ecotoxicology、Environmental Chemistry、Environmental Safety etc.