The effect of peppermint (Mentha piperita. L) essential oil aromatherapy on premenstrual syndrome: A randomized controlled trial protocol

IF 1.7 Q2 Medicine

Advances in integrative medicine Pub Date : 2025-04-24 DOI:10.1016/j.aimed.2025.100489

Yegane Lagzian , Fatemeh Mohammadzadeh , Fatemeh Yaghoobi Moghadam , Negar Shafaei Bajestani , Fariba Askari

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引用次数: 0

Abstract

Introduction

Premenstrual syndrome refers to a set of distressing and recurring psychological, behavioral, and somatic symptoms that usually begin from the ovulation and continue until the onset of menstruation. Today, many women use complementary medicine, especially medicinal plants, to control this syndrome. So far, the therapeutic effects of several medicinal plants used for this syndrome have been confirmed; however, the effectiveness of some of these plants, including peppermint, is still unclear. Therefore, the present study aims to determine the effect of peppermint essential oil aromatherapy on premenstrual syndrome.

Methods

This parallel-group, single-blinded, randomized controlled trial will be conducted on students with premenstrual syndrome living in dormitories of Gonabad University of Medical Sciences, Gonabad, Iran, in two parallel groups. Cluster random sampling will be performed. First, two dormitories will be randomly selected out of the four by lottery, and randomly assign them to the intervention and control groups. Then, in each dormitory, using the list of residents and generating random numbers online, some students will be randomly selected. Peppermint essential oil composition will be identified by gas chromatography–mass spectrometry. Participants in the intervention group will receive peppermint essential oil at 10 % purity, and the control group will receive odorless sweet almond oil as placebo to inhale from seven days before menstruation until the fourth day of menstrual bleeding for two consecutive cycles. The Premenstrual Symptoms Screening Tool questionnaire will be completed before, one, and two months after the intervention. The validity and reliability of this questionnaire have been confirmed in various studies. Data will be analyzed using SPSS-21 software.

Discussion

The results of this study will provide rigorous scientific evidence regarding the inhalation use of peppermint essential oil in managing premenstrual syndrome. If a significant positive correlation is observed in the intervention group, the use of this essential oil can be recommended to women suffering from this syndrome.

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薄荷（薄荷）的作用。精油芳香疗法治疗经前期综合征：一项随机对照试验方案

经前综合征是指一组令人痛苦的、反复出现的心理、行为和身体症状，通常从排卵开始，一直持续到月经开始。今天，许多妇女使用补充药物，特别是药用植物，来控制这种综合征。到目前为止，几种用于该综合征的药用植物的治疗效果已得到证实；然而，其中一些植物的有效性，包括薄荷，仍然不清楚。因此，本研究旨在确定薄荷精油芳香疗法对经前综合征的影响。方法采用平行组、单盲、随机对照试验，将伊朗戈纳巴德市戈纳巴德医科大学宿舍的经前综合征学生分为两个平行组。将进行整群随机抽样。首先，从四个宿舍中随机抽取两个宿舍，并将其随机分配到干预组和对照组。然后，在每个宿舍，使用居民名单并在网上生成随机数，随机选择一些学生。采用气相色谱-质谱联用技术鉴定薄荷精油的成分。干预组的参与者将获得纯度为10% %的薄荷精油，对照组将获得无味的甜杏仁油作为安慰剂，从月经前7天开始吸入，直到月经出血的第4天，连续两个周期。经前症状筛查工具问卷将在干预前、干预后1个月和干预后2个月完成。本问卷的效度和信度已在各种研究中得到证实。数据将使用SPSS-21软件进行分析。本研究的结果将为吸入薄荷精油治疗经前期综合征提供严格的科学证据。如果在干预组中观察到显著的正相关，则可以向患有该综合征的妇女推荐使用这种精油。

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来源期刊

Advances in integrative medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.20

自引率

11.80%

发文量

审稿时长

15 weeks

期刊介绍： Advances in Integrative Medicine (AIMED) is an international peer-reviewed, evidence-based research and review journal that is multi-disciplinary within the fields of Integrative and Complementary Medicine. The journal focuses on rigorous quantitative and qualitative research including systematic reviews, clinical trials and surveys, whilst also welcoming medical hypotheses and clinically-relevant articles and case studies disclosing practical learning tools for the consulting practitioner. By promoting research and practice excellence in the field, and cross collaboration between relevant practitioner groups and associations, the journal aims to advance the practice of IM, identify areas for future research, and improve patient health outcomes. International networking is encouraged through clinical innovation, the establishment of best practice and by providing opportunities for cooperation between organisations and communities.