Divergent trends in the burden of esophageal, gastric, and liver cancers in China

IF 7.6 Q1 ONCOLOGY
Yongjie Xu, Changfa Xia, Jiachen Wang, Yujie Wu, Wanqing Chen
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Abstract

Background

While China’s socioeconomic transformation has driven divergent trends in gastrointestinal cancers, comprehensive data on esophageal, gastric, and liver cancer burden remain limited. This study examines the global burden of esophageal, gastric, and liver cancers in 2022 and analyzes the trends of age-standardized incidence and mortality rate (ASRs) in China from 2000 to 2018, thereby providing evidence for the formulation of cancer control strategies.

Methods

The global burden of esophageal, gastric and liver cancers including the estimated number of cases and deaths and the ASRs for incidence and mortality were from GLOBALCAN 2022 dataset. Data from 22 cancer registries in China were employed for the trend analysis of the ASRs for incidence and mortality of these three cancers. The Joinpoint model was used to compute the average annual percentage change (AAPC) of the incidence and mortality of the three cancers from 2000 to 2018.

Results

Globally, esophageal, gastric and liver cancers accounted for 11.8 % of incident cancer cases and 19.1 % of cancer deaths. China bore a disproportionately high burden, representing 43.8 %, 37.0 %, and 42.4 % of global esophageal, gastric, and liver cancer cases respectively, and 42.1 %, 39.4 %, and 41.7 % of corresponding deaths. However, the ASRs for incidence and mortality for all three cancers declined significantly in China (2000–2018), with absolute case numbers decreasing for gastric and esophageal cancers during 2010–2022. Age-specific analysis revealed most pronounced declines in incidence and mortality in populations under 40 years old, with AAPCs of less than –6.0 % for esophageal cancer, around –4.0 % for gastric cancer, and approximately –2.0 % for liver cancer.

Conclusions

China has achieved remarkable progress in controlling esophageal, gastric and liver cancers, yet these malignancies remain major public health challenges. Future efforts should intensify existing prevention measures while expanding screening programs, particularly for aging populations. These findings offer valuable insights for regions undergoing similar epidemiological transitions.
中国食管癌、胃癌和肝癌负担的不同趋势
虽然中国的社会经济转型推动了胃肠道癌症的不同趋势,但关于食管癌、胃癌和肝癌负担的综合数据仍然有限。本研究考察了2022年全球食管癌、胃癌和肝癌的负担,并分析了2000 - 2018年中国年龄标准化发病率和死亡率(ASRs)的趋势,从而为制定癌症控制策略提供证据。方法食管癌、胃癌和肝癌的全球负担,包括估计的病例数和死亡人数以及发病率和死亡率的asr,来自GLOBALCAN 2022数据集。来自中国22个癌症登记处的数据被用于这三种癌症的发病率和死亡率的asr趋势分析。使用Joinpoint模型计算了2000年至2018年三种癌症发病率和死亡率的平均年百分比变化(AAPC)。结果在全球范围内,食管癌、胃癌和肝癌占癌症发病率的11.8%,占癌症死亡人数的19.1%。中国承担了不成比例的高负担,分别占全球食管癌、胃癌和肝癌病例的43.8%、37.0%和42.4%,相应的死亡人数分别占42.1%、39.4%和41.7%。然而,这三种癌症的发病率和死亡率的asr在中国(2000-2018年)显著下降,胃癌和食管癌的绝对病例数在2010-2022年期间下降。年龄特异性分析显示,40岁以下人群的发病率和死亡率下降最为明显,食管癌的AAPCs低于- 6.0%,胃癌约为- 4.0%,肝癌约为- 2.0%。结论中国在控制食管癌、胃癌和肝癌方面取得了显著进展,但这些恶性肿瘤仍是主要的公共卫生挑战。未来的努力应加强现有的预防措施,同时扩大筛查项目,特别是针对老龄化人口。这些发现为正在经历类似流行病学转变的地区提供了有价值的见解。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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