The role of exosomes in bladder cancer immunotherapy

IF 7.6 Q1 ONCOLOGY
Mohammad Mousaei Ghasroldasht, Piyush K. Agarwal
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引用次数: 0

Abstract

Bladder cancer remains a significant global health challenge, requiring repeated treatments and surveillance and potentially morbid therapies, particularly in advanced and recurrent stages. Exosomes, small extracellular vesicles central to intercellular communication, have emerged as innovative tools in cancer diagnostics, prognosis, and therapy. Their role in modulating the immune response and the tumor microenvironment makes them particularly attractive for cancer immunotherapy. This review provides a comprehensive overview of exosome biology, with a focus on their role in immune modulation and potential therapeutic applications. We explore the progress and challenges of exosome-based immunotherapy in cancer, followed by a discussion on the current state of bladder cancer immunotherapy. Additionally, we highlight the roles of exosomes in bladder cancer, emphasizing their diagnostic and prognostic applications. Despite promising preclinical studies and a growing number of clinical trials in other cancers, exosome-based therapies remain underexplored in bladder cancer. We discuss the current clinical trials related to exosomes in bladder cancer and propose their potential future role in immunotherapy. Finally, we address the challenges and opportunities in translating exosome-based therapies from bench to bedside, emphasizing the need for further preclinical and clinical investigations. This review emphasized the potential of exosome-based immunotherapy as a transformative approach for bladder cancer diagnosis and treatment.
外泌体在膀胱癌免疫治疗中的作用
膀胱癌仍然是一个重大的全球健康挑战,需要反复治疗和监测以及潜在的病态治疗,特别是在晚期和复发阶段。外泌体是细胞间通讯的中心细胞外小泡,已成为癌症诊断、预后和治疗的创新工具。它们在调节免疫反应和肿瘤微环境中的作用使它们对癌症免疫治疗特别有吸引力。本文综述了外泌体生物学的全面概述,重点介绍了它们在免疫调节中的作用和潜在的治疗应用。我们探讨了基于外泌体的免疫治疗在癌症中的进展和挑战,然后讨论了膀胱癌免疫治疗的现状。此外,我们强调外泌体在膀胱癌中的作用,强调它们的诊断和预后应用。尽管有前景的临床前研究和越来越多的其他癌症的临床试验,基于外泌体的治疗在膀胱癌方面仍未得到充分的探索。我们讨论了目前与膀胱癌外泌体相关的临床试验,并提出了它们在免疫治疗中的潜在作用。最后,我们讨论了将基于外泌体的疗法从实验室转化为床边的挑战和机遇,强调需要进一步的临床前和临床研究。这篇综述强调了基于外泌体的免疫治疗作为膀胱癌诊断和治疗的一种变革性方法的潜力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
CiteScore
14.20
自引率
0.00%
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审稿时长
70 days
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