Neurocognitive indices of response inhibition within Autogenous and Reactive Obsessions: A brief review

IF 1.9 4区医学 Q3 PSYCHIATRY

Journal of Obsessive-Compulsive and Related Disorders Pub Date : 2025-06-22 DOI:10.1016/j.jocrd.2025.100968

Zachary T. Gemelli, Henry D. Berger, Han-Joo Lee

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Abstract

Obsessive-compulsive disorder (OCD) is a heterogenous and debilitating condition in which roughly half of patients show limited long-term improvement. Improving our understanding on its heterogeneity may help optimize and enhance overall treatment outcomes of OCD. Among various subtyping approaches that currently exist for OCD the Autogenous-Reactive Obsession (AO-RO) subtyping taxonomy has continued to demonstrate high validity with empirical support in clinical and non-clinical samples. Furthermore, growing evidence indicates distinct neurocognitive profiles for AO and RO across studies and neuroimaging modalities within response inhibition indices. Specifically, results demonstrate AO is primarily characterized by deficits in cognitive inhibition, whereas some evidence suggests RO may be primarily characterized by deficits in behavioral inhibition. This article reviews the neurocognitive profiles of AO and RO and discusses the potential clinical utility of understanding their neurocognitive indices in improving treatment outcome for OCD.

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自体和反应性强迫中反应抑制的神经认知指标：简要综述

强迫症（OCD）是一种异质性和衰弱性疾病，大约一半的患者表现出有限的长期改善。提高我们对其异质性的理解可能有助于优化和提高强迫症的整体治疗效果。在目前存在的各种强迫症亚型方法中，自体反应性强迫症（AO-RO）亚型分类法在临床和非临床样本中继续显示出高度的有效性。此外，越来越多的证据表明，在反应抑制指数的研究和神经成像模式中，AO和RO的神经认知特征不同。具体而言，结果表明AO主要以认知抑制缺陷为特征，而一些证据表明RO可能主要以行为抑制缺陷为特征。本文综述了AO和RO的神经认知特征，并讨论了了解它们的神经认知指标在改善强迫症治疗效果方面的潜在临床应用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Obsessive-Compulsive and Related Disorders PSYCHIATRY-

CiteScore

4.00

自引率

5.60%

发文量

审稿时长

47 days

期刊介绍： Journal of Obsessive-Compulsive and Related Disorders (JOCRD) is an international journal that publishes high quality research and clinically-oriented articles dealing with all aspects of obsessive-compulsive disorder (OCD) and related conditions (OC spectrum disorders; e.g., trichotillomania, hoarding, body dysmorphic disorder). The journal invites studies of clinical and non-clinical (i.e., student) samples of all age groups from the fields of psychiatry, psychology, neuroscience, and other medical and health sciences. The journal''s broad focus encompasses classification, assessment, psychological and psychiatric treatment, prevention, psychopathology, neurobiology and genetics. Clinical reports (descriptions of innovative treatment methods) and book reviews on all aspects of OCD-related disorders will be considered, as will theoretical and review articles that make valuable contributions. Suitable topics for manuscripts include: -The boundaries of OCD and relationships with OC spectrum disorders -Validation of assessments of obsessive-compulsive and related phenomena -OCD symptoms in diverse social and cultural contexts -Studies of neurobiological and genetic factors in OCD and related conditions -Experimental and descriptive psychopathology and epidemiological studies -Studies on relationships among cognitive and behavioral variables in OCD and related disorders -Interpersonal aspects of OCD and related disorders -Evaluation of psychological and psychiatric treatment and prevention programs, and predictors of outcome.