Multi-component reactions using selenium powder: Synthesis of 4,5-dihydro-1,3-selenazol-2-amine derivatives

Abstract

A method of synthesis of 4,5-dihydro-1,3-selenazole-2-amine derivatives with three components promoted by triethylamine was proposed. The method utilizes selenium powder as a safe, low-cost selenium source and isocyanides as nitrogen donors, achieving high yields under mild, straightforward conditions. This reaction constructs two C–Se bonds and one C–N bond in a single step, with excellent substrate scope and functional group tolerance. Its simplicity, high atom economy, and use of non-toxic, inexpensive materials make it a practical and sustainable strategy for synthesizing bioactive organoselenium compounds, overcoming limitations of traditional approaches.