Yunhao You, Shaoqiu Leng, Jie Shi, Han Yang, Mingzheng Chang, Qingliang Ma, Dapeng Zhang, Haochen Sun, Lianlei Wang*, Zhiliang Gao*, Jiwei Cui* and Xinyu Liu*,
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引用次数: 0
Abstract
Nanomedicines hold great promise for the treatment of osteoporosis, while their nonspecific accumulation in the liver typically reduces the drug delivery efficacy. Herein, we report bone-targeted liposomes encapsulated with arginine and metformin for the treatment of osteoporosis. These liposomes are functionalized with alendronate to enhance the bone-targeting capability. The delivered agents directly modulate osteoblasts, osteoclasts, and osteocytes, promoting bone formation and inhibiting bone resorption to counteract osteoporotic bone loss. In addition to targeted bone delivery, the inevitable hepatic accumulation of liposomes is strategically utilized to stimulate the hepatic secretion of lecithin-cholesterol acyltransferase (LCAT), which, in turn, promotes bone remodeling by engaging the liver-bone axis. This dual mechanism, which combines targeted bone delivery with beneficial off-target hepatic effects, synergistically enhances therapeutic outcomes. Our findings highlight a promising nanomedicine-based strategy that takes advantage of interorgan communication to optimize osteoporosis treatment.
期刊介绍:
ACS Nano, published monthly, serves as an international forum for comprehensive articles on nanoscience and nanotechnology research at the intersections of chemistry, biology, materials science, physics, and engineering. The journal fosters communication among scientists in these communities, facilitating collaboration, new research opportunities, and advancements through discoveries. ACS Nano covers synthesis, assembly, characterization, theory, and simulation of nanostructures, nanobiotechnology, nanofabrication, methods and tools for nanoscience and nanotechnology, and self- and directed-assembly. Alongside original research articles, it offers thorough reviews, perspectives on cutting-edge research, and discussions envisioning the future of nanoscience and nanotechnology.