Fat taste sensitivity in women with obesity: transcriptomic analysis of fungiform papillae before and after bariatric surgery

IF 4.7 2区 医学 Q1 ENDOCRINOLOGY & METABOLISM
Obesity Pub Date : 2025-06-22 DOI:10.1002/oby.24325
Arnaud Bernard, Corentin Richard, Loredana Radoi, Romain Boidot, Séverine Ledoux, Philippe Besnard
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引用次数: 0

Abstract

Objective

Fat taste sensitivity has been implicated in long-term weight loss after bariatric surgery. Unexpectedly, improvement of orosensory fat acuity was not systematic in operated patients.

Methods

Obesity-induced alterations of gene expression in gustatory papillae having been recently reported, we have explored the fungiform transcriptomic activity in the bariatric surgery context. Fat taste detection thresholds (three-alternative ascending forced-choice tests) alongside transcriptomic profiling of freshly isolated fungiform papillae were assessed in women with severe obesity before and 6 months after sleeve gastrectomy.

Results

According to evolution of post surgery detection thresholds, lipid-improved and -unimproved subgroups were identified, despite similar initial anthropometric parameters. Lower weight loss and higher plasma fasting insulin, C-reactive protein, and fibrinogen levels distinguished lipid-unimproved patients. This subgroup also overexpressed genes involved in inflammation and apoptosis, with certain ones being positively correlated with high lipid detection thresholds (low sensitivity), whereas the key gene of taste bud cell signaling, TRPM5, was down-expressed. In lipid-improved patients, genes implicated in cell renewal, neuronal function, and receptor recycling were upregulated and associated with better lipid detection efficiency. Pathway enrichment identified immune and anti-inflammatory activities in lipid-unimproved and -improved groups, respectively.

Conclusions

These findings collectively suggest that changes in gene expression within gustatory papillae contribute to fat taste sensitivity after sleeve gastrectomy.

Abstract Image

肥胖女性的脂肪味觉敏感性:减肥手术前后真菌状乳头的转录组学分析
目的:脂肪味觉敏感性与减肥手术后的长期体重减轻有关。出乎意料的是,手术患者的口腔感觉脂肪敏锐度的改善并不是系统性的。方法:肥胖引起的味觉乳头基因表达的改变最近有报道,我们探索了减肥手术背景下真菌的转录组活性。在袖胃切除术前和术后6个月重度肥胖妇女中,评估了脂肪味道检测阈值(三种选择上升强迫选择测试)和新鲜分离的真菌状乳头转录组学分析。结果:尽管初始人体测量参数相似,但根据术后检测阈值的演变,确定了脂质改善和未改善亚组。较低的体重减轻和较高的血浆空腹胰岛素、c反应蛋白和纤维蛋白原水平区分了血脂未改善的患者。该亚群还过度表达与炎症和凋亡相关的基因,部分基因与高脂质检测阈值(低敏感性)呈正相关,而味蕾细胞信号传导的关键基因TRPM5则下调表达。在脂质改善的患者中,与细胞更新、神经元功能和受体循环有关的基因被上调,并与更好的脂质检测效率相关。途径富集分别鉴定了脂质未改善组和改善组的免疫和抗炎活性。结论:这些发现共同表明,味觉乳头内基因表达的变化有助于袖胃切除术后脂肪味觉的敏感性。
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来源期刊
Obesity
Obesity 医学-内分泌学与代谢
CiteScore
11.70
自引率
1.40%
发文量
261
审稿时长
2-4 weeks
期刊介绍: Obesity is the official journal of The Obesity Society and is the premier source of information for increasing knowledge, fostering translational research from basic to population science, and promoting better treatment for people with obesity. Obesity publishes important peer-reviewed research and cutting-edge reviews, commentaries, and public health and medical developments.
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