Differential Cardiac Remodeling in Overweight and Obesity: Insights from Noninvasive Imaging.

IF 4.7 3区 医学 Q2 ENDOCRINOLOGY & METABOLISM
Obesity Facts Pub Date : 2025-06-21 DOI:10.1159/000546406
Wenjun Liu, Shanshan Li, Yue Yu, Lele Cheng, Zixuan Meng, Yaxuan Xue, Renjie Liu, Hui Liu, Jian Yang, Yue Wu, Zhijie Jian
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引用次数: 0

Abstract

Introduction: Weight gain is associated with cardiac abnormalities, but the differences in cardiac remodeling between overweight and obesity (O&O) remain unclear. This study explored the structural and functional cardiac changes associated with O&O using noninvasive imaging.

Methods: A retrospective study included participants from August 2021 to July 2023. Clinical data, laboratory results, and echocardiography reports were collected, and cardiac magnetic resonance imaging was post-processed. Cardiac structural and functional parameters were compared among healthy weight, overweight, and obesity groups, and their relationships with body mass index (BMI) were analyzed.

Results: A total of 275 participants were included. Significant differences in left ventricular end-diastolic/systolic diameters, left atrial diameter, left ventricular ejection fraction, and stroke volume index were observed between O&O and healthy weight groups (p < 0.05). However, no significant differences were found between the O&O groups in terms of left ventricular septum thickness, left ventricular posterior wall thickness, cardiac index, or end-systolic volume index (p > 0.05). Multivariable regression showed a positive correlation between BMI and cardiac structural/functional indicators (p < 0.05), with greater changes in obesity. Loess spline analysis revealed that cardiac remodeling was more pronounced during the overweight stage.

Conclusions: Both O&O are associated with larger cardiac dimensions, increased myocardial mass, and impaired function. Cardiac remodeling accelerates during the overweight stage, emphasizing the need for early detection and intervention in overweight individuals to mitigate future health risks.

超重和肥胖的不同心脏重构:来自无创成像的见解。
体重增加与心脏异常有关,但超重和肥胖在心脏重塑方面的差异尚不清楚。本研究利用无创成像技术探讨与O&;O相关的心脏结构和功能改变。方法回顾性研究纳入2021年8月至2023年7月的参与者。收集临床资料、实验室结果和超声心动图报告,并对心脏磁共振(CMR)成像进行后处理。比较健康体重组、超重组和肥胖组的心脏结构和功能参数,并分析其与身体质量指数(BMI)的关系。结果共纳入受试者275人。左室舒张末期/收缩期内径、左房内径、左室射血分数(LVEF)、卒中容积(LVSV)指数在0、0体重组与健康体重组间差异均有统计学意义(P0.05)。多变量回归显示BMI与心脏结构/功能指标呈正相关(P
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来源期刊
Obesity Facts
Obesity Facts 医学-内分泌学与代谢
CiteScore
6.80
自引率
5.60%
发文量
77
审稿时长
6-12 weeks
期刊介绍: ''Obesity Facts'' publishes articles covering all aspects of obesity, in particular epidemiology, etiology and pathogenesis, treatment, and the prevention of adiposity. As obesity is related to many disease processes, the journal is also dedicated to all topics pertaining to comorbidity and covers psychological and sociocultural aspects as well as influences of nutrition and exercise on body weight. The editors carefully select papers to present only the most recent findings in clinical practice and research. All professionals concerned with obesity issues will find this journal a most valuable update to keep them abreast of the latest scientific developments.
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