From Inner Sense to Outer Action: Interoception and Impulsive Compulsive Behavior Disorders in Parkinson's Disease.

IF 2.6 4区医学 Q2 CLINICAL NEUROLOGY

Movement Disorders Clinical Practice Pub Date : 2025-06-23 DOI:10.1002/mdc3.70187

Chiara Baiano, Francesca Morgante, Diana Goeta, Chiara Giacobbe, Marianna Amboni, Carmine Vitale, Elena Makovac, Benedetta Demartini, Gabriella Santangelo, Lucia Ricciardi

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引用次数: 0

Abstract

Background: Impulsive-compulsive behavior disorders (ICBDs) in Parkinson's disease (PD) include impulse control disorders (ICDs) and compulsive behaviors, often linked to dopaminergic treatment and altered reward processing. Interoception, the perception of internal bodily signals, plays a key role in emotional regulation and decision-making. Neuroimaging studies suggest that alterations in interoceptive and reward-related brain circuits may underlie ICDs in PD. However, the relationship between interoception and ICDs remains underexplored.

Objective: To investigate the relationship between impulse control disorders (ICD) severity and interoceptive abilities-specifically interoceptive accuracy, insight, and self-reported interoception-in PD patients.

Methods: Fifty-one participants were assessed using the Questionnaire for Impulsive-Compulsive Disorders in Parkinson's Disease Rating Scale (QUIP-RS) alongside measures of interoceptive performance, anxiety, depression, and apathy.

Results: Higher ICD severity predicted increased interoceptive insight and sensibility. No significant link was found between ICD severity and interoceptive accuracy. Additionally, higher Levodopa Equivalent Daily Dose (LEDD) was related to lower interoceptive insight, suggesting a potential modulatory effect of dopaminergic therapy on meta-cognitive interoception.

Conclusions: These findings highlight the complex interplay between ICDs and interoception, suggesting that heightened self-reported interoception and interoceptive insight may reinforce impulsive behaviors in PD via enhanced bodily signal salience. This study contributes to understanding the characteristics of ICDs in PD, implicating reward-related circuits such as the insula and anterior cingulate cortex.

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从内在感觉到外在行为：帕金森氏病的内感受和冲动强迫行为障碍。

背景：帕金森病（PD）的冲动强迫行为障碍（icbd）包括冲动控制障碍（ICDs）和强迫行为，通常与多巴胺能治疗和奖励加工改变有关。内感受是对身体内部信号的感知，在情绪调节和决策中起着关键作用。神经影像学研究表明，内部感受性和奖励相关脑回路的改变可能是PD中icd的基础。然而，内感受与icd之间的关系仍未得到充分探讨。目的：探讨PD患者冲动控制障碍（ICD）严重程度与内感受能力（特别是内感受准确性、洞察力和自述内感受）之间的关系。方法：采用帕金森病冲动性强迫症评定量表（QUIP-RS）和内感受性表现、焦虑、抑郁和冷漠量表对51名参与者进行评估。结果：较高的ICD严重程度预示着内感受性洞察力和敏感性的增加。没有发现ICD严重程度和内感受准确性之间的显著联系。此外，较高的左旋多巴当量日剂量（LEDD）与较低的内感受洞察力相关，表明多巴胺能治疗对元认知内感受有潜在的调节作用。结论：这些发现强调了icd与内感受之间复杂的相互作用，表明自我报告的内感受和内感受顿悟可能通过增强身体信号显著性来强化PD患者的冲动行为。这项研究有助于理解PD中ICDs的特征，包括脑岛和前扣带皮层等与奖励相关的回路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Movement Disorders Clinical Practice CLINICAL NEUROLOGY-

CiteScore

4.00

自引率

7.50%

发文量

218

期刊介绍： Movement Disorders Clinical Practice- is an online-only journal committed to publishing high quality peer reviewed articles related to clinical aspects of movement disorders which broadly include phenomenology (interesting case/case series/rarities), investigative (for e.g- genetics, imaging), translational (phenotype-genotype or other) and treatment aspects (clinical guidelines, diagnostic and treatment algorithms)