Negative Second PET-CT 1 Year After Treatment of Oropharyngeal Cancer Predicts Low Mortality and Recurrence

IF 1.5 4区医学 Q2 OTORHINOLARYNGOLOGY

Clinical Otolaryngology Pub Date : 2025-06-22 DOI:10.1111/coa.70003

Nir Livneh, Chen Weinstein Wexler, Gilad Feinmesser, Iris Granot, Eran Alon

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引用次数: 0

Abstract

Objective

To determine the prediction value of a second PET-CT imaging study performed 1 year after treatment for patients with oropharyngeal carcinoma.

Methods

A Retrospective single-institution tertiary care centre study. Included are all patients diagnosed with oropharyngeal cancer between 2010 and 2020 at a tertiary medical centre. All 77 suitable patients completed at least two ET-CT scans during the post-treatment period, the first at 3 months and the second at 1 year. The follow-up extended to 5 years after treatment. The main outcome measures were overall survival (OS) and disease-free survival (DFS).

Results

In total, 55 (65%) patients had no evidence of disease (NED) on the 1-year PET-CT. The negative predictive value of 1-year PET-CT was 91% for 4-year DFS and 100% for 4-year OS. Regression analysis of NED on the 1-year PET-CT correlated with 5-year DFS (odds ratio [OR] 55, 95% confidence interval [CI] 5.2–500, p = 0.001) and low probability of 5-year recurrence rates (OR 11.23, 1.23–100, p = 0.03).

Conclusions

The findings of this study demonstrate that NED on PET-CT performed 1 year after the completion of treatment for oropharyngeal cancer is indicative of very low recurrence rates and almost non-existent mortality. We suggest performing a second PET-CT study at 1 year post-treatment on all patients with negative results on the first one performed at 3 months post-treatment. Negative findings on the second study may allow for a more lenient clinical follow-up protocol.

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口咽癌治疗1年后第二次PET-CT阴性预测低死亡率和复发率。

目的：确定在口咽癌患者治疗1年后进行的第二次PET-CT影像学研究的预测价值。方法：回顾性单机构三级保健中心研究。纳入的是2010年至2020年间在三级医疗中心诊断为口咽癌的所有患者。所有77名合适的患者在治疗后完成了至少两次ET-CT扫描，第一次在3个月时，第二次在1年时。治疗后随访时间延长至5年。主要结局指标为总生存期（OS）和无病生存期（DFS）。结果：55例（65%）患者在1年的PET-CT上没有疾病（NED）的证据。1年PET-CT的4年DFS阴性预测值为91%，4年OS阴性预测值为100%。回归分析1年PET-CT上NED与5年DFS相关（比值比[OR] 55, 95%可信区间[CI] 5.2 ~ 500, p = 0.001）， 5年复发率低概率（OR 11.23, 1.23 ~ 100, p = 0.03）。结论：本研究的结果表明，口咽癌治疗完成1年后PET-CT上的NED表明复发率非常低，几乎不存在死亡率。我们建议在治疗后1年对所有在治疗后3个月进行第一次阴性结果的患者进行第二次PET-CT研究。第二项研究的阴性结果可能允许更宽松的临床随访方案。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical Otolaryngology 医学-耳鼻喉科学

CiteScore

4.00

自引率

4.80%

发文量

106

审稿时长

>12 weeks

期刊介绍： Clinical Otolaryngology is a bimonthly journal devoted to clinically-oriented research papers of the highest scientific standards dealing with: current otorhinolaryngological practice audiology, otology, balance, rhinology, larynx, voice and paediatric ORL head and neck oncology head and neck plastic and reconstructive surgery continuing medical education and ORL training The emphasis is on high quality new work in the clinical field and on fresh, original research. Each issue begins with an editorial expressing the personal opinions of an individual with a particular knowledge of a chosen subject. The main body of each issue is then devoted to original papers carrying important results for those working in the field. In addition, topical review articles are published discussing a particular subject in depth, including not only the opinions of the author but also any controversies surrounding the subject. • Negative/null results In order for research to advance, negative results, which often make a valuable contribution to the field, should be published. However, articles containing negative or null results are frequently not considered for publication or rejected by journals. We welcome papers of this kind, where appropriate and valid power calculations are included that give confidence that a negative result can be relied upon.