The role of oral microbiota and tooth loss in cardiovascular disease risk: a systematic review.

IF 2 3区生物学 Q3 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biofouling Pub Date : 2025-08-01 Epub Date: 2025-06-23 DOI:10.1080/08927014.2025.2518280

Pillar Gonçalves Pizziolo, Cláudia Helena Silva-Lovato, Lorena Mosconi Clemente, Angelica Carandina, Helio Cesar Salgado, Thais Marques da Silva, Eleonora Tobaldini, Nicola Montano, Adriana Barbosa Ribeiro

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引用次数: 0

Abstract

This systematic review explores the relationship between the oral microbiome in edentulous patients and cardiovascular diseases (CVD). A search was conducted across databases PubMed, Scopus, Web of Science, Embase, and gray literature sources. The review followed PRISMA and AMSTAR guidelines. After removing duplicates, the articles were evaluated by titles and abstracts, and 21 were selected for full-text review, with 9 ultimately included in the final analysis. Oral dysbiosis, linked to systemic conditions like obesity, diabetes, and CVD, is common in inflammatory oral diseases such as periodontitis and denture stomatitis, disrupting original oral microbiota. This imbalance may lead to transient bacteremia and systemic inflammation, contributing to CVD development. Tooth loss reduces salivary microbiome diversity, and denture use in CVD patients is linked to decreased life expectancy compared to dentate individuals. The findings suggest tooth loss, denture use, and oral microbiota dysbiosis are unconventional risk factors for CVD progression.

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口腔微生物群和牙齿脱落在心血管疾病风险中的作用：一项系统综述

本系统综述探讨无牙患者口腔微生物组与心血管疾病（CVD）之间的关系。在PubMed、Scopus、Web of Science、Embase和灰色文献来源数据库中进行了搜索。审查遵循PRISMA和AMSTAR指南。去除重复后，根据题目和摘要对文章进行评价，选出21篇进行全文审阅，其中9篇最终纳入最终分析。口腔生态失调与肥胖、糖尿病和心血管疾病等全身性疾病有关，在牙周炎和假牙口炎等炎症性口腔疾病中很常见，破坏了原有的口腔微生物群。这种不平衡可能导致短暂的菌血症和全身性炎症，促进心血管疾病的发展。牙齿脱落会减少唾液微生物群的多样性，与有牙齿的人相比，心血管疾病患者使用假牙与预期寿命缩短有关。研究结果表明，牙齿脱落、假牙使用和口腔微生物群失调是心血管疾病进展的非常规危险因素。

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来源期刊

Biofouling 生物-海洋与淡水生物学

CiteScore

5.00

自引率

7.40%

发文量

审稿时长

1.7 months

期刊介绍： Biofouling is an international, peer-reviewed, multi-discliplinary journal which publishes original articles and mini-reviews and provides a forum for publication of pure and applied work on protein, microbial, fungal, plant and animal fouling and its control, as well as studies of all kinds on biofilms and bioadhesion. Papers may be based on studies relating to characterisation, attachment, growth and control on any natural (living) or man-made surface in the freshwater, marine or aerial environments, including fouling, biofilms and bioadhesion in the medical, dental, and industrial context. Specific areas of interest include antifouling technologies and coatings including transmission of invasive species, antimicrobial agents, biological interfaces, biomaterials, microbiologically influenced corrosion, membrane biofouling, food industry biofilms, biofilm based diseases and indwelling biomedical devices as substrata for fouling and biofilm growth, including papers based on clinically-relevant work using models that mimic the realistic environment in which they are intended to be used.