Copper(II)-Catalyzed Regioselective Cascade Reaction of β,γ-Alkynyl-α-Imino Esters with α-Amino Acid-Derived Esters.

Abstract

A cascade reaction between β,γ-alkynyl-α-imino esters and α-amino acid-derived esters has been developed, enabling the efficient synthesis of a series of novel α-amino acid derivatives featuring oxazolone moieties under mild reaction conditions. Control experiments and mechanistic studies were conducted to elucidate the reaction pathway and gain insights into the underlying process.