Lei Xu, Wenjing Lou, Fan Xu, Yujiao Xie, Yue Hu, Liting Xie, Chengyue Zhang, Aochi Liu, Xinyu Miao, Zhiwei Hou, Wenyuan Ma, Qiyu Zhao, Jie Lin, Aiguo Wu and Tianan Jiang
{"title":"Enhancing pancreatic cancer ablation efficiency: bipolar IRE with conductive MOF†","authors":"Lei Xu, Wenjing Lou, Fan Xu, Yujiao Xie, Yue Hu, Liting Xie, Chengyue Zhang, Aochi Liu, Xinyu Miao, Zhiwei Hou, Wenyuan Ma, Qiyu Zhao, Jie Lin, Aiguo Wu and Tianan Jiang","doi":"10.1039/D4QM01041H","DOIUrl":null,"url":null,"abstract":"<p >Irreversible electroporation (IRE) has emerged as a promising therapeutic modality for pancreatic cancer. However, traditional IRE techniques rely on high-voltage electric fields and require precise alignment of multiple electrodes, which complicates the procedure and increases associated risks. To address these challenges, we developed a novel “bipolar” IRE electrode that combines both the cathode and anode into a single device, simplifying the procedure and potentially reducing operational risks. Additionally, we incorporated a conductive metal–organic framework (MOF) to enhance the electric field distribution of the electric field, thereby improving the efficacy of tumor ablation. Mechanistic studies revealed that this combined approach induces tumor cell apoptosis and improves the consistency of ablation outcomes. Both <em>in vitro</em> and <em>in vivo</em> experiments demonstrated that the bipolar electrode, in combination with the conductive MOF, achieved a significant apoptosis rate of 59.95% ± 2.41 <em>in vitro</em> and resulted in an 85.77% ± 0.21 reduction in tumor volume in <em>in vivo</em> models, without any adverse effects. This approach provides a more optimized and potentially more effective solution for treating pancreatic cancer.</p>","PeriodicalId":86,"journal":{"name":"Materials Chemistry Frontiers","volume":" 13","pages":" 2018-2030"},"PeriodicalIF":6.4000,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Materials Chemistry Frontiers","FirstCategoryId":"88","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2025/qm/d4qm01041h","RegionNum":2,"RegionCategory":"材料科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
引用次数: 0
Abstract
Irreversible electroporation (IRE) has emerged as a promising therapeutic modality for pancreatic cancer. However, traditional IRE techniques rely on high-voltage electric fields and require precise alignment of multiple electrodes, which complicates the procedure and increases associated risks. To address these challenges, we developed a novel “bipolar” IRE electrode that combines both the cathode and anode into a single device, simplifying the procedure and potentially reducing operational risks. Additionally, we incorporated a conductive metal–organic framework (MOF) to enhance the electric field distribution of the electric field, thereby improving the efficacy of tumor ablation. Mechanistic studies revealed that this combined approach induces tumor cell apoptosis and improves the consistency of ablation outcomes. Both in vitro and in vivo experiments demonstrated that the bipolar electrode, in combination with the conductive MOF, achieved a significant apoptosis rate of 59.95% ± 2.41 in vitro and resulted in an 85.77% ± 0.21 reduction in tumor volume in in vivo models, without any adverse effects. This approach provides a more optimized and potentially more effective solution for treating pancreatic cancer.
期刊介绍:
Materials Chemistry Frontiers focuses on the synthesis and chemistry of exciting new materials, and the development of improved fabrication techniques. Characterisation and fundamental studies that are of broad appeal are also welcome.
This is the ideal home for studies of a significant nature that further the development of organic, inorganic, composite and nano-materials.